Human recombinant interleukin-1 alpha increases elastase-like enzyme in human uterine cervical fibroblasts.

Published

Journal Article

Production of the elastase-like enzyme, Suc-(Ala)3-p-nitroanilide hydrolase, was examined in human uterine cervical fibroblasts. The metallo-dependent enzyme is present in both media and cellular fractions. Human recombinant interleukin-1 alpha stimulated cells to produce and secrete this elastase-like enzyme. These results suggest that modulation of this enzyme activity by interleukin-1 may play a significant role in the ripening and dilation of the cervix, because elastin is a component of the uterine cervix and its peptides are known to be chemotactic for leukocytes.

Full Text

Duke Authors

Cited Authors

  • Ito, A; Leppert, PC; Mori, Y

Published Date

  • 1990

Published In

Volume / Issue

  • 30 / 4

Start / End Page

  • 239 - 241

PubMed ID

  • 2289704

Pubmed Central ID

  • 2289704

International Standard Serial Number (ISSN)

  • 0378-7346

Digital Object Identifier (DOI)

  • 10.1159/000293277

Language

  • eng

Conference Location

  • Switzerland