A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.
Journal Article (Journal Article;Review)
This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.
Full Text
Duke Authors
Cited Authors
- Leppert, PC; Catherino, WH; Segars, JH
Published Date
- August 2006
Published In
Volume / Issue
- 195 / 2
Start / End Page
- 415 - 420
PubMed ID
- 16635466
Pubmed Central ID
- PMC4143906
Electronic International Standard Serial Number (EISSN)
- 1097-6868
Digital Object Identifier (DOI)
- 10.1016/j.ajog.2005.12.059
Language
- eng
Conference Location
- United States