A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.

Journal Article (Journal Article;Review)

This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.

Full Text

Duke Authors

Cited Authors

  • Leppert, PC; Catherino, WH; Segars, JH

Published Date

  • August 2006

Published In

Volume / Issue

  • 195 / 2

Start / End Page

  • 415 - 420

PubMed ID

  • 16635466

Pubmed Central ID

  • PMC4143906

Electronic International Standard Serial Number (EISSN)

  • 1097-6868

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2005.12.059


  • eng

Conference Location

  • United States