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Epstein-Barr-associated leiomyomatosis and T-cell chimerism after haploidentical bone marrow transplantation for severe combined immunodeficiency disease.

Publication ,  Journal Article
Atluri, S; Neville, K; Davis, M; Robertson, KA; Marshalleck, FE; O'Malley, DP; Buckley, RH; Nelson, RP
Published in: J Pediatr Hematol Oncol
March 2007

BACKGROUND: The clinical course of Epstein-Barr virus (EBV)-associated smooth muscle tumors is variable and there are no reports in patients with mixed T-cell chimerism after bone marrow transplantation (BMT). OBSERVATIONS: A child with X-linked severe combined immunodeficiency disease developed multiple renal and pulmonary leiomyomata 8 years after haploidentical BMT. Epstein-Barr viral DNA was detectable in the blood and in situ hybridization for EBV-encoded RNAs was positive in the tumor. The tumors have been radiographically stable, chimerism remains mixed, and plasma EBV DNA has been repeatedly negative for over 2 years after donor lymphocyte infusion. CONCLUSIONS: EBV-associated smooth muscle tumors may occur in patients who are partially reconstituted after BMT for severe combined immunodeficiency and may not require surgery or chemotherapy.

Duke Scholars

Published In

J Pediatr Hematol Oncol

DOI

ISSN

1077-4114

Publication Date

March 2007

Volume

29

Issue

3

Start / End Page

166 / 172

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • T-Lymphocytes
  • Severe Combined Immunodeficiency
  • Sensitivity and Specificity
  • Oncology & Carcinogenesis
  • Male
  • Lung Neoplasms
  • Leiomyomatosis
  • Kidney Neoplasms
  • Humans
 

Citation

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Atluri, S., Neville, K., Davis, M., Robertson, K. A., Marshalleck, F. E., O’Malley, D. P., … Nelson, R. P. (2007). Epstein-Barr-associated leiomyomatosis and T-cell chimerism after haploidentical bone marrow transplantation for severe combined immunodeficiency disease. J Pediatr Hematol Oncol, 29(3), 166–172. https://doi.org/10.1097/MPH.0b013e31803b95b3
Atluri, Srilatha, Kathleen Neville, Mary Davis, Kent A. Robertson, Francis E. Marshalleck, Dennis P. O’Malley, Rebecca H. Buckley, and Robert P. Nelson. “Epstein-Barr-associated leiomyomatosis and T-cell chimerism after haploidentical bone marrow transplantation for severe combined immunodeficiency disease.J Pediatr Hematol Oncol 29, no. 3 (March 2007): 166–72. https://doi.org/10.1097/MPH.0b013e31803b95b3.
Atluri S, Neville K, Davis M, Robertson KA, Marshalleck FE, O’Malley DP, et al. Epstein-Barr-associated leiomyomatosis and T-cell chimerism after haploidentical bone marrow transplantation for severe combined immunodeficiency disease. J Pediatr Hematol Oncol. 2007 Mar;29(3):166–72.
Atluri, Srilatha, et al. “Epstein-Barr-associated leiomyomatosis and T-cell chimerism after haploidentical bone marrow transplantation for severe combined immunodeficiency disease.J Pediatr Hematol Oncol, vol. 29, no. 3, Mar. 2007, pp. 166–72. Pubmed, doi:10.1097/MPH.0b013e31803b95b3.
Atluri S, Neville K, Davis M, Robertson KA, Marshalleck FE, O’Malley DP, Buckley RH, Nelson RP. Epstein-Barr-associated leiomyomatosis and T-cell chimerism after haploidentical bone marrow transplantation for severe combined immunodeficiency disease. J Pediatr Hematol Oncol. 2007 Mar;29(3):166–172.

Published In

J Pediatr Hematol Oncol

DOI

ISSN

1077-4114

Publication Date

March 2007

Volume

29

Issue

3

Start / End Page

166 / 172

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • T-Lymphocytes
  • Severe Combined Immunodeficiency
  • Sensitivity and Specificity
  • Oncology & Carcinogenesis
  • Male
  • Lung Neoplasms
  • Leiomyomatosis
  • Kidney Neoplasms
  • Humans