The multiple causes of human SCID.

Journal Article (Journal Article)

SCID, a syndrome characterized by the absence of T cells and adaptive immunity, can result from mutations in multiple genes that encode components of the immune system. Three such components are cytokine receptor chains or signaling molecules, five are needed for antigen receptor development, one is adenosine deaminase--a purine salvage pathway enzyme, and the last is a phosphatase, CD45. In this issue of the JCI, a report describes how complete deficiency of the CD3epsilon chain of the T cell antigen receptor/CD3 complex causes human SCID.

Full Text

Duke Authors

Cited Authors

  • Buckley, RH

Published Date

  • November 2004

Published In

Volume / Issue

  • 114 / 10

Start / End Page

  • 1409 - 1411

PubMed ID

  • 15545990

Pubmed Central ID

  • PMC525750

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI23571


  • eng

Conference Location

  • United States