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Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction.

Publication ,  Journal Article
Gu, B; Reiter, JP; Schwinn, DA; Smith, MP; Korstanje, C; Thor, KB; Dolber, PC
Published in: The Journal of urology
August 2004

PURPOSE: Antagonists of alpha 1-adrenergic receptors (alpha 1ARs) relieve obstructive and irritative symptoms in patients with bladder outlet obstruction. However, to our knowledge mechanisms underlying the relief of irritative symptoms remain unknown. Because bladder alpha 1dARs are up-regulated in some rats with bladder outlet obstruction, we investigated the effect of the alpha 1aAR antagonist 5-methyl urapidil (5MU) vs the alpha 1a/alpha 1dAR antagonist tamsulosin on urinary frequency in obstructed rats. MATERIALS AND METHODS: Baseline frequency was measured using a chronic micturition recording system and then obstruction (40 rats) or sham obstruction surgery (11 rats) was performed. After 6 weeks frequency was reassessed, followed by subcutaneous implantation of osmotic pumps to deliver 5MU, tamsulosin or vehicle for 1 week. Upon the completion of drug treatment urinary frequency was again measured and the pressor response to the alpha 1AR agonist phenylephrine was documented. RESULTS: Obstructed bladder mass was an average of 4.9 times greater than bladder mass in sham operated rats (p

Duke Scholars

Published In

The Journal of urology

ISSN

0022-5347

Publication Date

August 2004

Volume

172

Issue

2

Start / End Page

758 / 762

Location

united states

Related Subject Headings

  • Urology & Nephrology
  • Urination
  • Urinary Bladder Neck Obstruction
  • Tamsulosin
  • Sulfonamides
  • Regression Analysis
  • Rats, Sprague-Dawley
  • Rats
  • Piperazines
  • Phenylephrine
 

Citation

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Gu, B., Reiter, J. P., Schwinn, D. A., Smith, M. P., Korstanje, C., Thor, K. B., & Dolber, P. C. (2004). Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction. The Journal of Urology, 172(2), 758–762.
Gu, B., J. P. Reiter, D. A. Schwinn, M. P. Smith, C. Korstanje, K. B. Thor, and P. C. Dolber. “Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction.The Journal of Urology 172, no. 2 (August 2004): 758–62.
Gu B, Reiter JP, Schwinn DA, Smith MP, Korstanje C, Thor KB, et al. Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction. The Journal of urology. 2004 Aug;172(2):758–62.
Gu B, Reiter JP, Schwinn DA, Smith MP, Korstanje C, Thor KB, Dolber PC. Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction. The Journal of urology. 2004 Aug;172(2):758–762.
Journal cover image

Published In

The Journal of urology

ISSN

0022-5347

Publication Date

August 2004

Volume

172

Issue

2

Start / End Page

758 / 762

Location

united states

Related Subject Headings

  • Urology & Nephrology
  • Urination
  • Urinary Bladder Neck Obstruction
  • Tamsulosin
  • Sulfonamides
  • Regression Analysis
  • Rats, Sprague-Dawley
  • Rats
  • Piperazines
  • Phenylephrine