Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction.

Journal Article (Academic article)

PURPOSE: Antagonists of alpha 1-adrenergic receptors (alpha 1ARs) relieve obstructive and irritative symptoms in patients with bladder outlet obstruction. However, to our knowledge mechanisms underlying the relief of irritative symptoms remain unknown. Because bladder alpha 1dARs are up-regulated in some rats with bladder outlet obstruction, we investigated the effect of the alpha 1aAR antagonist 5-methyl urapidil (5MU) vs the alpha 1a/alpha 1dAR antagonist tamsulosin on urinary frequency in obstructed rats. MATERIALS AND METHODS: Baseline frequency was measured using a chronic micturition recording system and then obstruction (40 rats) or sham obstruction surgery (11 rats) was performed. After 6 weeks frequency was reassessed, followed by subcutaneous implantation of osmotic pumps to deliver 5MU, tamsulosin or vehicle for 1 week. Upon the completion of drug treatment urinary frequency was again measured and the pressor response to the alpha 1AR agonist phenylephrine was documented. RESULTS: Obstructed bladder mass was an average of 4.9 times greater than bladder mass in sham operated rats (p

Duke Authors

Cited Authors

  • Gu, B; Reiter, JP; Schwinn, DA; Smith, MP; Korstanje, C; Thor, KB; Dolber, PC

Published Date

  • August 2004

Published In

Volume / Issue

  • 172 / 2

Start / End Page

  • 758 - 762

PubMed ID

  • 15247777

International Standard Serial Number (ISSN)

  • 0022-5347

Conference Location

  • united states