Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.
Journal Article (Journal Article)
OBJECTIVE: To examine the relationships among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality. The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. MAOA-uVNTR genotype has been associated with both psychological and physical measures. METHODS: The sample consisted of 74 males enrolled in a case/control study of caregivers for relatives with dementia. Age- and race-adjusted linear regression models were used to examine the association between low versus high MAOA-uVNTR activity alleles, symptoms of depression (Center for Epidemiological Studies of Depression), and sleep quality ratings (Pittsburgh Sleep Quality Index). RESULTS: MAOA-uVNTR alleles associated with less transcriptional activity were related to increased symptoms of depression (p < .04; Cohen's d = 0.52) and poorer sleep quality (p < .04; Cohen's d = 0.31). CONCLUSIONS: Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep.
Full Text
Duke Authors
- Ashley-Koch, Allison Elizabeth
- Brummett, Beverly H.
- Krystal, Andrew Darrell
- Kuhn, Cynthia Moreton
- Siegler, Ilene C.
- Surwit, Richard Samuel
- Williams Jr., Redford B.
Cited Authors
- Brummett, BH; Krystal, AD; Siegler, IC; Kuhn, C; Surwit, RS; Züchner, S; Ashley-Koch, A; Barefoot, JC; Williams, RB
Published Date
- June 2007
Published In
Volume / Issue
- 69 / 5
Start / End Page
- 396 - 401
PubMed ID
- 17585061
Pubmed Central ID
- PMC2777888
Electronic International Standard Serial Number (EISSN)
- 1534-7796
Digital Object Identifier (DOI)
- 10.1097/PSY.0b013e31806d040b
Language
- eng
Conference Location
- United States