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Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.

Publication ,  Journal Article
Brummett, BH; Krystal, AD; Siegler, IC; Kuhn, C; Surwit, RS; Züchner, S; Ashley-Koch, A; Barefoot, JC; Williams, RB
Published in: Psychosom Med
June 2007

OBJECTIVE: To examine the relationships among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality. The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. MAOA-uVNTR genotype has been associated with both psychological and physical measures. METHODS: The sample consisted of 74 males enrolled in a case/control study of caregivers for relatives with dementia. Age- and race-adjusted linear regression models were used to examine the association between low versus high MAOA-uVNTR activity alleles, symptoms of depression (Center for Epidemiological Studies of Depression), and sleep quality ratings (Pittsburgh Sleep Quality Index). RESULTS: MAOA-uVNTR alleles associated with less transcriptional activity were related to increased symptoms of depression (p < .04; Cohen's d = 0.52) and poorer sleep quality (p < .04; Cohen's d = 0.31). CONCLUSIONS: Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep.

Duke Scholars

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

June 2007

Volume

69

Issue

5

Start / End Page

396 / 401

Location

United States

Related Subject Headings

  • Tandem Repeat Sequences
  • Sleep Wake Disorders
  • Risk
  • Psychiatry
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Monoamine Oxidase
  • Middle Aged
  • Male
  • Humans
 

Citation

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ICMJE
MLA
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Brummett, B. H., Krystal, A. D., Siegler, I. C., Kuhn, C., Surwit, R. S., Züchner, S., … Williams, R. B. (2007). Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med, 69(5), 396–401. https://doi.org/10.1097/PSY.0b013e31806d040b
Brummett, Beverly H., Andrew D. Krystal, Ilene C. Siegler, Cynthia Kuhn, Richard S. Surwit, Stephan Züchner, Allison Ashley-Koch, John C. Barefoot, and Redford B. Williams. “Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.Psychosom Med 69, no. 5 (June 2007): 396–401. https://doi.org/10.1097/PSY.0b013e31806d040b.
Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, Züchner S, et al. Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med. 2007 Jun;69(5):396–401.
Brummett, Beverly H., et al. “Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.Psychosom Med, vol. 69, no. 5, June 2007, pp. 396–401. Pubmed, doi:10.1097/PSY.0b013e31806d040b.
Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, Züchner S, Ashley-Koch A, Barefoot JC, Williams RB. Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med. 2007 Jun;69(5):396–401.

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

June 2007

Volume

69

Issue

5

Start / End Page

396 / 401

Location

United States

Related Subject Headings

  • Tandem Repeat Sequences
  • Sleep Wake Disorders
  • Risk
  • Psychiatry
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Monoamine Oxidase
  • Middle Aged
  • Male
  • Humans