Antigen-induced arthritis. Decreased proteoglycan content and inhibition of proteoglycan synthesis in articular cartilage.

Journal Article (Journal Article)

An arthritis was induced in rabbits immunized with human serum albumin by injection of antigen into the hind knee joint. Histological changes in the synovial membrane and an increase in polymorphonuclear granulocytes in the synovial fluid indicated an inflammatory response similar to that described with fibrin as antigen (1). The arthritis was accompanied by no significant change in the collagen content, but a marked decrease in the proteoglycan content of the cartilage was noted. Cartilage from inflamed joints generally exhibited a decreased ability to synthesize proteoglycan in vitro.

Full Text

Duke Authors

Cited Authors

  • Lowther, DA; Sandy, JD; Santer, VB; Brown, HL

Published Date

  • 1978

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 675 - 680

PubMed ID

  • 736998

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.1780210611


  • eng

Conference Location

  • United States