Hepatitis B antigen in saliva, urine, and stool.

Journal Article (Journal Article)

A survey of hepatitis B patients, asymptomatic hepatitis B antigen (HBsAg) carriers, and control subjects was conducted to determine the relationship between antigenemia and antigen excretion in saliva, urine, and stool. Radioimmunoassay was used to detect HBsAg. Specificity-confirmed HBsAg was detected in the saliva of 6 (30%) of 20 antigenemic patients, 1 (5%) of 20 nonantigenemic patients, 14 (34%) of 41 carriers, and 0 of 112 controls. HBsAg was detected in urine only after 100-fold concentration of first-morning specimens. Specificity-confirmed HBsAg was present in the urine of 7 (16%) of 43 carriers; unconfirmed HBsAg was found in the urine of 5 (13%) of 38 patients and 5 (5%) of 112 controls. Unconfirmed HBsAg was detected in concentrated stool specimens from 5 (46%) of 11 patients and 3 of 8 carriers and controls. Longitudinally collected specimens from antigenemic subjects showed no consistent patterns of antigen excretion.

Full Text

Duke Authors

Cited Authors

  • Irwin, GR; Allen, AM; Bancroft, WH; Karwacki, JJ; Brown, HL; Pinkerton, RH; Willhight, M; Top, FH

Published Date

  • January 1975

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 142 - 145

PubMed ID

  • 1116873

Pubmed Central ID

  • PMC415037

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/iai.11.1.142-145.1975


  • eng

Conference Location

  • United States