Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.


Journal Article

Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells where it functions as a transcription factor. Although EGFR has transactivational activity, it lacks a DNA binding domain and, therefore, may require a DNA binding transcription cofactor for its transcriptional function. Here, we report that EGFR physically interacts with signal transducers and activators of transcription 3 (STAT3) in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase (iNOS). In breast carcinomas, nuclear EGFR positively correlates with iNOS. This study describes a mode of transcriptional control involving cooperated efforts of STAT3 and nuclear EGFR. Our work suggests that the deregulated iNOS/NO pathway may partly contribute to the malignant biology of tumor cells with high levels of nuclear EGFR and STAT3.

Full Text

Cited Authors

  • Lo, H-W; Hsu, S-C; Ali-Seyed, M; Gunduz, M; Xia, W; Wei, Y; Bartholomeusz, G; Shih, J-Y; Hung, M-C

Published Date

  • June 2005

Published In

Volume / Issue

  • 7 / 6

Start / End Page

  • 575 - 589

PubMed ID

  • 15950906

Pubmed Central ID

  • 15950906

International Standard Serial Number (ISSN)

  • 1535-6108

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2005.05.007


  • eng

Conference Location

  • United States