Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance.

Published

Journal Article (Review)

The human glutathione S-transferase, GSTs, possess both enzymatic and non-enzymatic functions and are involved in many important cellular processes, such as, phase II metabolism, stress response, cell proliferation, apoptosis, oncogenesis, tumor progression and drug resistance. The non-enzymatic functions of GSTs involve their interactions with cellular proteins, such as, JNK, TRAF, ASK, PKC, and TGM2, during which, either the interacting protein partner undergoes functional alteration or the GST protein itself is post-translationally modified and/or functionally altered. The majority of GST genes harbor polymorphisms that influence their transcription and/or function of their encoded proteins. This overview focuses on recent insights into the biology and pharmacogenetics of GSTs as a determinant of cancer drug resistance and response of cancer patients to therapy.

Full Text

Duke Authors

Cited Authors

  • Lo, H-W; Ali-Osman, F

Published Date

  • August 6, 2007

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 367 - 374

PubMed ID

  • 17681492

Pubmed Central ID

  • 17681492

Electronic International Standard Serial Number (EISSN)

  • 1471-4973

International Standard Serial Number (ISSN)

  • 1471-4892

Digital Object Identifier (DOI)

  • 10.1016/j.coph.2007.06.009

Language

  • eng