Effect of delta9-tetrahydrocannabinol on in vitro sensitization of mouse splenic lymphocytes.


Journal Article

The effects of delta9-tetrahydrocannabinol (delta9-THC) on the immune response of murine cells sensitized in vitro was determined using a plaque-forming cell (PFC) assay. Splenic lymphocytes from mice injected with delta9-THC showed a depressed immunologic response when compared with cells from control animals which were identically sensitized in vitro with sheep erythrocytes (SRBC). The direct addition of delta9-THC to the culture media altered the immunological response as demonstrated by a reduction in the number of PFC.

Full Text

Duke Authors

Cited Authors

  • Lefkowitz, SS; Klager, K

Published Date

  • 1978

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 557 - 566

PubMed ID

  • 359460

Pubmed Central ID

  • 359460

International Standard Serial Number (ISSN)

  • 0090-0877

Digital Object Identifier (DOI)

  • 10.3109/08820137809025484


  • eng

Conference Location

  • United States