Immunosuppression of mice by delta-9-tetrahydrocannabinol.

Journal Article (Journal Article)

Studies were initiated to determine the effects of delta-9-tetrahydrocannibinol (THC) on the production of indirect IgG plaque-forming and rosette-forming cells in mice. BDF1 mice were immunized with sheep erythrocytes followed by multiple injections of 10, 25 or 40 mg/kg THC. Results indicated that both parameters were significantly reduced by 25 mg/kg, thus affirming the immunosuppressive properties of this substance in mice.

Full Text

Duke Authors

Cited Authors

  • Lefkowitz, SS; Klager, K; Nemeth, D; Pruess, M

Published Date

  • January 1, 1978

Published In

Volume / Issue

  • 19 / 1

Start / End Page

  • 101 - 107

PubMed ID

  • 343205

International Standard Serial Number (ISSN)

  • 0034-5164


  • eng

Conference Location

  • United States