Skip to main content

In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones.

Publication ,  Journal Article
Millington, DS; Golder, MP; Cowley, T; London, D; Roberts, H; Butt, WR; Griffiths, K
Published in: Acta Endocrinol (Copenh)
July 1976

The study describes the effects of ACTH, prolactin and other protein hormones on the synthesis and secretion of steroid hormones by tissue from a feminising adrenocortical carcinoma removed from a post-menopausal female. Steroid production by the tissue was determined by high resolution-mass fragmentography and by radioimmunoassay. Prolactin and ACTH stimulated the synthesis of estrogens by the tissue whereas GH, LH and ACTH were more effective than prolactin in stimulating androgen synthesis. The effect of protein hormones, other than ACTH, on adenylate cyclase activity of this tumour tissue indicated a lack of specificity of the membrane receptor sites.

Duke Scholars

Published In

Acta Endocrinol (Copenh)

DOI

ISSN

0001-5598

Publication Date

July 1976

Volume

82

Issue

3

Start / End Page

561 / 571

Location

Denmark

Related Subject Headings

  • Radioimmunoassay
  • Prolactin
  • Humans
  • Gonadal Steroid Hormones
  • Gas Chromatography-Mass Spectrometry
  • Female
  • Culture Techniques
  • Culture Media
  • Chromatography, Gas
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Millington, D. S., Golder, M. P., Cowley, T., London, D., Roberts, H., Butt, W. R., & Griffiths, K. (1976). In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones. Acta Endocrinol (Copenh), 82(3), 561–571. https://doi.org/10.1530/acta.0.0820561
Millington, D. S., M. P. Golder, T. Cowley, D. London, H. Roberts, W. R. Butt, and K. Griffiths. “In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones.Acta Endocrinol (Copenh) 82, no. 3 (July 1976): 561–71. https://doi.org/10.1530/acta.0.0820561.
Millington DS, Golder MP, Cowley T, London D, Roberts H, Butt WR, et al. In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones. Acta Endocrinol (Copenh). 1976 Jul;82(3):561–71.
Millington, D. S., et al. “In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones.Acta Endocrinol (Copenh), vol. 82, no. 3, July 1976, pp. 561–71. Pubmed, doi:10.1530/acta.0.0820561.
Millington DS, Golder MP, Cowley T, London D, Roberts H, Butt WR, Griffiths K. In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones. Acta Endocrinol (Copenh). 1976 Jul;82(3):561–571.

Published In

Acta Endocrinol (Copenh)

DOI

ISSN

0001-5598

Publication Date

July 1976

Volume

82

Issue

3

Start / End Page

561 / 571

Location

Denmark

Related Subject Headings

  • Radioimmunoassay
  • Prolactin
  • Humans
  • Gonadal Steroid Hormones
  • Gas Chromatography-Mass Spectrometry
  • Female
  • Culture Techniques
  • Culture Media
  • Chromatography, Gas
  • Aged