Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry.
Journal Article (Journal Article)
Urine samples from three children at different stages of chronic valproate therapy were partially purified using a cation exchange column. A signal consistent with either valproylcarnitine or octanoylcarnitine was observed in one of these extracts by direct fast atom bombardment-mass spectrometry analysis. These isomeric acylcarnitines were synthesized, separated and characterized by thermospray high performance liquid chromatography-mass spectrometry. This new technique was then employed to positively identify intact valproyl-carnitine in the patients' urine samples. The implications of this finding with regard to a mechanism to account for carnitine deficiency in patients receiving valproate are discussed.
Full Text
Duke Authors
Cited Authors
- Millington, DS; Bohan, TP; Roe, CR; Yergey, AL; Liberato, DJ
Published Date
- January 15, 1985
Published In
Volume / Issue
- 145 / 1
Start / End Page
- 69 - 76
PubMed ID
- 3919970
Pubmed Central ID
- 3919970
International Standard Serial Number (ISSN)
- 0009-8981
Digital Object Identifier (DOI)
- 10.1016/0009-8981(85)90020-8
Language
- eng
Conference Location
- Netherlands