Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry.

Published

Journal Article

Urine samples from three children at different stages of chronic valproate therapy were partially purified using a cation exchange column. A signal consistent with either valproylcarnitine or octanoylcarnitine was observed in one of these extracts by direct fast atom bombardment-mass spectrometry analysis. These isomeric acylcarnitines were synthesized, separated and characterized by thermospray high performance liquid chromatography-mass spectrometry. This new technique was then employed to positively identify intact valproyl-carnitine in the patients' urine samples. The implications of this finding with regard to a mechanism to account for carnitine deficiency in patients receiving valproate are discussed.

Full Text

Duke Authors

Cited Authors

  • Millington, DS; Bohan, TP; Roe, CR; Yergey, AL; Liberato, DJ

Published Date

  • January 15, 1985

Published In

Volume / Issue

  • 145 / 1

Start / End Page

  • 69 - 76

PubMed ID

  • 3919970

Pubmed Central ID

  • 3919970

International Standard Serial Number (ISSN)

  • 0009-8981

Language

  • eng

Conference Location

  • Netherlands