Nursery neurobiologic risk score: levels of risk and relationships with nonmedical factors.

Journal Article (Journal Article)

This study compares the Neurobiologic Risk Score (NBRS) with developmental outcome in 199 infants < or = 1500 g birth weight to determine levels of risk and to investigate the relative contributions of the NBRS and nonmedical factors to developmental outcome. The NBRS correlated significantly (p < .0001) with the Bayley Mental (MDI) and Psychomotor (PDI) Indexes, and neurologic examination score (NS) at 6, 15, and 24 months. Three risk groups were identified: low, NBRS < or = 4; intermediate, NBRS 5 to 7; and high, NBRS > or = 8 with an incidence of major handicaps at 24 months of 7%, 32%, and 50%, respectively. Of eight factors considered, the NBRS accounted for the greatest variance: MDI, 14 to 27%; PDI, 25 to 29%; NS, 34 to 42%. Additional increments of variance were contributed by gender (MDI, PDI, NS), maternal intelligence and race (MDI), and maternal education (PDI). The NBRS is a useful tool for identifying risk for developmental abnormalities due to neonatal medical events.

Full Text

Duke Authors

Cited Authors

  • Brazy, JE; Goldstein, RF; Oehler, JM; Gustafson, KE; Thompson, RJ

Published Date

  • December 1993

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 375 - 380

PubMed ID

  • 8126229

International Standard Serial Number (ISSN)

  • 0196-206X


  • eng

Conference Location

  • United States