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In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.

Publication ,  Journal Article
Singh, H; Singh, JR; Dhillon, VS; Bali, D; Paul, H
Published in: Mutat Res
July 1, 1994

Genotoxicity evaluation of a widely used glucocorticoid medicine, dexamethasone, was undertaken using in vitro and in vivo assays. Analyses of chromosomal aberrations, sister-chromatid exchanges (SCEs) in human lymphocytes and micronuclei and SCEs in mouse bone marrow showed the drug to be capable of attacking the genetic material. However, the Ames/Salmonella assay, both with and without S9 mix, did not show any increase in His+ revertants.

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Published In

Mutat Res

DOI

ISSN

0027-5107

Publication Date

July 1, 1994

Volume

308

Issue

1

Start / End Page

89 / 97

Location

Netherlands

Related Subject Headings

  • Sister Chromatid Exchange
  • Salmonella typhi
  • Oncology & Carcinogenesis
  • Mutagens
  • Mutagenicity Tests
  • Micronucleus Tests
  • Mice
  • Male
  • Humans
  • Dexamethasone
 

Citation

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Singh, H., Singh, J. R., Dhillon, V. S., Bali, D., & Paul, H. (1994). In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. Mutat Res, 308(1), 89–97. https://doi.org/10.1016/0027-5107(94)90201-1
Singh, H., J. R. Singh, V. S. Dhillon, D. Bali, and H. Paul. “In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.Mutat Res 308, no. 1 (July 1, 1994): 89–97. https://doi.org/10.1016/0027-5107(94)90201-1.
Singh H, Singh JR, Dhillon VS, Bali D, Paul H. In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. Mutat Res. 1994 Jul 1;308(1):89–97.
Singh, H., et al. “In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.Mutat Res, vol. 308, no. 1, July 1994, pp. 89–97. Pubmed, doi:10.1016/0027-5107(94)90201-1.
Singh H, Singh JR, Dhillon VS, Bali D, Paul H. In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. Mutat Res. 1994 Jul 1;308(1):89–97.
Journal cover image

Published In

Mutat Res

DOI

ISSN

0027-5107

Publication Date

July 1, 1994

Volume

308

Issue

1

Start / End Page

89 / 97

Location

Netherlands

Related Subject Headings

  • Sister Chromatid Exchange
  • Salmonella typhi
  • Oncology & Carcinogenesis
  • Mutagens
  • Mutagenicity Tests
  • Micronucleus Tests
  • Mice
  • Male
  • Humans
  • Dexamethasone