In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.
Publication
, Journal Article
Singh, H; Singh, JR; Dhillon, VS; Bali, D; Paul, H
Published in: Mutat Res
July 1, 1994
Genotoxicity evaluation of a widely used glucocorticoid medicine, dexamethasone, was undertaken using in vitro and in vivo assays. Analyses of chromosomal aberrations, sister-chromatid exchanges (SCEs) in human lymphocytes and micronuclei and SCEs in mouse bone marrow showed the drug to be capable of attacking the genetic material. However, the Ames/Salmonella assay, both with and without S9 mix, did not show any increase in His+ revertants.
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Published In
Mutat Res
DOI
ISSN
0027-5107
Publication Date
July 1, 1994
Volume
308
Issue
1
Start / End Page
89 / 97
Location
Netherlands
Related Subject Headings
- Sister Chromatid Exchange
- Salmonella typhi
- Oncology & Carcinogenesis
- Mutagens
- Mutagenicity Tests
- Micronucleus Tests
- Mice
- Male
- Humans
- Dexamethasone
Citation
APA
Chicago
ICMJE
MLA
NLM
Singh, H., Singh, J. R., Dhillon, V. S., Bali, D., & Paul, H. (1994). In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. Mutat Res, 308(1), 89–97. https://doi.org/10.1016/0027-5107(94)90201-1
Singh, H., J. R. Singh, V. S. Dhillon, D. Bali, and H. Paul. “In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.” Mutat Res 308, no. 1 (July 1, 1994): 89–97. https://doi.org/10.1016/0027-5107(94)90201-1.
Singh H, Singh JR, Dhillon VS, Bali D, Paul H. In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. Mutat Res. 1994 Jul 1;308(1):89–97.
Singh, H., et al. “In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.” Mutat Res, vol. 308, no. 1, July 1994, pp. 89–97. Pubmed, doi:10.1016/0027-5107(94)90201-1.
Singh H, Singh JR, Dhillon VS, Bali D, Paul H. In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. Mutat Res. 1994 Jul 1;308(1):89–97.
Published In
Mutat Res
DOI
ISSN
0027-5107
Publication Date
July 1, 1994
Volume
308
Issue
1
Start / End Page
89 / 97
Location
Netherlands
Related Subject Headings
- Sister Chromatid Exchange
- Salmonella typhi
- Oncology & Carcinogenesis
- Mutagens
- Mutagenicity Tests
- Micronucleus Tests
- Mice
- Male
- Humans
- Dexamethasone