In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.
Genotoxicity evaluation of a widely used glucocorticoid medicine, dexamethasone, was undertaken using in vitro and in vivo assays. Analyses of chromosomal aberrations, sister-chromatid exchanges (SCEs) in human lymphocytes and micronuclei and SCEs in mouse bone marrow showed the drug to be capable of attacking the genetic material. However, the Ames/Salmonella assay, both with and without S9 mix, did not show any increase in His+ revertants.
Singh, H; Singh, JR; Dhillon, VS; Bali, D; Paul, H
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