In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.


Journal Article

Genotoxicity evaluation of a widely used glucocorticoid medicine, dexamethasone, was undertaken using in vitro and in vivo assays. Analyses of chromosomal aberrations, sister-chromatid exchanges (SCEs) in human lymphocytes and micronuclei and SCEs in mouse bone marrow showed the drug to be capable of attacking the genetic material. However, the Ames/Salmonella assay, both with and without S9 mix, did not show any increase in His+ revertants.

Full Text

Duke Authors

Cited Authors

  • Singh, H; Singh, JR; Dhillon, VS; Bali, D; Paul, H

Published Date

  • July 1, 1994

Published In

Volume / Issue

  • 308 / 1

Start / End Page

  • 89 - 97

PubMed ID

  • 7516489

Pubmed Central ID

  • 7516489

International Standard Serial Number (ISSN)

  • 0027-5107

Digital Object Identifier (DOI)

  • 10.1016/0027-5107(94)90201-1


  • eng

Conference Location

  • Netherlands