In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone.


Journal Article

Genotoxic evaluation of a widely used glucocorticoid, hydrocortisone, was undertaken using a battery of in vitro and in vivo test systems. Human lymphocyte cultures and mouse bone marrow studies (micronuclei and sister chromatid exchange analyses) showed the drug to be very potent clastogen. However, the Ames/Salmonella assay both with and without S9 did not show an increase in the His+ revertants.

Full Text

Duke Authors

Cited Authors

  • Bali, D; Singh, JR; Singh, H; Sandhu, D

Published Date

  • 1990

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 250 - 254

PubMed ID

  • 2253604

Pubmed Central ID

  • 2253604

International Standard Serial Number (ISSN)

  • 0893-6692

Digital Object Identifier (DOI)

  • 10.1002/em.2850160406


  • eng

Conference Location

  • United States