Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.

Published

Journal Article

Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.

Full Text

Duke Authors

Cited Authors

  • Amos, CI; Bali, D; Thiel, TJ; Anderson, JP; Gourley, I; Frazier, ML; Lynch, PM; Luchtefeld, MA; Young, A; McGarrity, TJ; Seldin, MF

Published Date

  • September 1, 1997

Published In

Volume / Issue

  • 57 / 17

Start / End Page

  • 3653 - 3656

PubMed ID

  • 9288765

Pubmed Central ID

  • 9288765

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States