Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.
Publication
, Journal Article
Amos, CI; Bali, D; Thiel, TJ; Anderson, JP; Gourley, I; Frazier, ML; Lynch, PM; Luchtefeld, MA; Young, A; McGarrity, TJ; Seldin, MF
Published in: Cancer Res
September 1, 1997
Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.
Duke Scholars
Published In
Cancer Res
ISSN
0008-5472
Publication Date
September 1, 1997
Volume
57
Issue
17
Start / End Page
3653 / 3656
Location
United States
Related Subject Headings
- Phenotype
- Peutz-Jeghers Syndrome
- Pedigree
- Oncology & Carcinogenesis
- Male
- Lod Score
- Humans
- Heterozygote
- Genetic Markers
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Amos, C. I., Bali, D., Thiel, T. J., Anderson, J. P., Gourley, I., Frazier, M. L., … Seldin, M. F. (1997). Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res, 57(17), 3653–3656.
Amos, C. I., D. Bali, T. J. Thiel, J. P. Anderson, I. Gourley, M. L. Frazier, P. M. Lynch, et al. “Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.” Cancer Res 57, no. 17 (September 1, 1997): 3653–56.
Amos CI, Bali D, Thiel TJ, Anderson JP, Gourley I, Frazier ML, et al. Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res. 1997 Sep 1;57(17):3653–6.
Amos, C. I., et al. “Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.” Cancer Res, vol. 57, no. 17, Sept. 1997, pp. 3653–56.
Amos CI, Bali D, Thiel TJ, Anderson JP, Gourley I, Frazier ML, Lynch PM, Luchtefeld MA, Young A, McGarrity TJ, Seldin MF. Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res. 1997 Sep 1;57(17):3653–3656.
Published In
Cancer Res
ISSN
0008-5472
Publication Date
September 1, 1997
Volume
57
Issue
17
Start / End Page
3653 / 3656
Location
United States
Related Subject Headings
- Phenotype
- Peutz-Jeghers Syndrome
- Pedigree
- Oncology & Carcinogenesis
- Male
- Lod Score
- Humans
- Heterozygote
- Genetic Markers
- Female