The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.
Published
Journal Article
Mutations in the gene for methylenetetrahydrofolate reductase (MTHFR) have been implicated as a risk factor in the formation of neural tube defects. We investigated this gene in a series of 65 sporadic American Caucasian patients with lumbosacral NTD and their unaffected parents, using both case-control design and assessment of linkage disequilibrium. We found no evidence to support mutations in MTHFR as a significant risk factor for NTD in this population.
Full Text
Duke Authors
Cited Authors
- Speer, MC; Worley, G; Mackey, JF; Melvin, E; Oakes, WJ; George, TM
Published Date
- September 1997
Published In
Volume / Issue
- 1 / 2
Start / End Page
- 149 - 150
PubMed ID
- 10732818
Pubmed Central ID
- 10732818
International Standard Serial Number (ISSN)
- 1364-6745
Digital Object Identifier (DOI)
- 10.1007/s100480050022
Language
- eng
Conference Location
- United States