Skip to main content
Journal cover image

The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.

Publication ,  Journal Article
Speer, MC; Worley, G; Mackey, JF; Melvin, E; Oakes, WJ; George, TM
Published in: Neurogenetics
September 1997

Mutations in the gene for methylenetetrahydrofolate reductase (MTHFR) have been implicated as a risk factor in the formation of neural tube defects. We investigated this gene in a series of 65 sporadic American Caucasian patients with lumbosacral NTD and their unaffected parents, using both case-control design and assessment of linkage disequilibrium. We found no evidence to support mutations in MTHFR as a significant risk factor for NTD in this population.

Duke Scholars

Published In

Neurogenetics

DOI

ISSN

1364-6745

Publication Date

September 1997

Volume

1

Issue

2

Start / End Page

149 / 150

Location

United States

Related Subject Headings

  • White People
  • Temperature
  • Risk Factors
  • Oxidoreductases Acting on CH-NH Group Donors
  • Neurology & Neurosurgery
  • Neural Tube Defects
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Male
  • Humans
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Speer, M. C., Worley, G., Mackey, J. F., Melvin, E., Oakes, W. J., & George, T. M. (1997). The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group. Neurogenetics, 1(2), 149–150. https://doi.org/10.1007/s100480050022
Speer, M. C., G. Worley, J. F. Mackey, E. Melvin, W. J. Oakes, and T. M. George. “The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.Neurogenetics 1, no. 2 (September 1997): 149–50. https://doi.org/10.1007/s100480050022.
Speer, M. C., et al. “The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.Neurogenetics, vol. 1, no. 2, Sept. 1997, pp. 149–50. Pubmed, doi:10.1007/s100480050022.
Journal cover image

Published In

Neurogenetics

DOI

ISSN

1364-6745

Publication Date

September 1997

Volume

1

Issue

2

Start / End Page

149 / 150

Location

United States

Related Subject Headings

  • White People
  • Temperature
  • Risk Factors
  • Oxidoreductases Acting on CH-NH Group Donors
  • Neurology & Neurosurgery
  • Neural Tube Defects
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Male
  • Humans
  • Genotype