The lung in sickle cell disease.

Journal Article (Journal Article;Review)

Sickle cell disease is the most common inherited disorder in African-Americans. Although the primary defect is hematological, the changes in the erythrocytes lead to a vasculopathy with multiorgan injury. The pulmonary complications, i.e., acute chest syndrome and chronic sickle cell lung disease, are significant causes of morbidity and mortality. The pulmonary manifestations result from a unique constellation of factors which come into play in sickle cell disease. Based on the growing understanding of the molecular and cellular biology of sickle cell disease, new therapies are being developed that are likely to ameliorate the natural history of this disease and its complications.

Full Text

Duke Authors

Cited Authors

  • Knight, J; Murphy, TM; Browning, I

Published Date

  • September 1999

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 205 - 216

PubMed ID

  • 10495338

International Standard Serial Number (ISSN)

  • 8755-6863

Digital Object Identifier (DOI)

  • 10.1002/(sici)1099-0496(199909)28:3<205::aid-ppul8>;2-z


  • eng

Conference Location

  • United States