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Length oscillation induces force potentiation in infant guinea pig airway smooth muscle.

Publication ,  Journal Article
Wang, L; Chitano, P; Murphy, TM
Published in: Am J Physiol Lung Cell Mol Physiol
December 2005

Deep inspiration counteracts bronchospasm in normal subjects but triggers further bronchoconstriction in hyperresponsive airways. Although the exact mechanisms for this contrary response by normal and hyperresponsive airways are unclear, it has been suggested that the phenomenon is related to changes in force-generating ability of airway smooth muscle after mechanical oscillation. It is known that healthy immature airways of both humans and animals exhibit hyperresponsiveness. We hypothesize that the profile of active force generation after mechanical oscillation changes with maturation and that this change contributes to the expression of airway hyperresponsiveness in juveniles. We examined the effect of an acute sinusoidal length oscillation on the force-generating ability of tracheal smooth muscle from 1 wk, 3 wk, and 2- to 3-mo-old guinea pigs. We found that the length oscillation produced 15-20% initial reduction in active force equally in all age groups. This was followed by a force recovery profile that displayed striking maturation-specific features. Unique to tracheal strips from 1-wk-old animals, active force potentiated beyond the maximal force generated before oscillation. We also found that actin polymerization was required in force recovery and that prostanoids contributed to the maturation-specific force potentiation in immature airway smooth muscle. Our results suggest a potentiated mechanosensitive contractile property of hyperresponsive airway smooth muscle. This can account for further bronchoconstriction triggered by deep inspiration in hyperresponsive airways.

Duke Scholars

Published In

Am J Physiol Lung Cell Mol Physiol

DOI

ISSN

1040-0605

Publication Date

December 2005

Volume

289

Issue

6

Start / End Page

L909 / L915

Location

United States

Related Subject Headings

  • Trachea
  • Stress, Mechanical
  • Respiratory System
  • Respiration
  • Muscle, Smooth
  • Muscle Contraction
  • Humans
  • Guinea Pigs
  • Constriction, Pathologic
  • Bronchial Spasm
 

Citation

APA
Chicago
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MLA
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Wang, L., Chitano, P., & Murphy, T. M. (2005). Length oscillation induces force potentiation in infant guinea pig airway smooth muscle. Am J Physiol Lung Cell Mol Physiol, 289(6), L909–L915. https://doi.org/10.1152/ajplung.00128.2005
Wang, Lu, Pasquale Chitano, and Thomas M. Murphy. “Length oscillation induces force potentiation in infant guinea pig airway smooth muscle.Am J Physiol Lung Cell Mol Physiol 289, no. 6 (December 2005): L909–15. https://doi.org/10.1152/ajplung.00128.2005.
Wang L, Chitano P, Murphy TM. Length oscillation induces force potentiation in infant guinea pig airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L909–15.
Wang, Lu, et al. “Length oscillation induces force potentiation in infant guinea pig airway smooth muscle.Am J Physiol Lung Cell Mol Physiol, vol. 289, no. 6, Dec. 2005, pp. L909–15. Pubmed, doi:10.1152/ajplung.00128.2005.
Wang L, Chitano P, Murphy TM. Length oscillation induces force potentiation in infant guinea pig airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L909–L915.

Published In

Am J Physiol Lung Cell Mol Physiol

DOI

ISSN

1040-0605

Publication Date

December 2005

Volume

289

Issue

6

Start / End Page

L909 / L915

Location

United States

Related Subject Headings

  • Trachea
  • Stress, Mechanical
  • Respiratory System
  • Respiration
  • Muscle, Smooth
  • Muscle Contraction
  • Humans
  • Guinea Pigs
  • Constriction, Pathologic
  • Bronchial Spasm