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Pars planitis: clinical features and class II HLA associations.

Publication ,  Journal Article
Raja, SC; Jabs, DA; Dunn, JP; Fekrat, S; Machan, CH; Marsh, MJ; Bressler, NM
Published in: Ophthalmology
March 1999

OBJECTIVE: To describe a cohort of patients with pars planitis followed at a single tertiary care institution, determine the frequency of multiple sclerosis and/or optic neuritis in patients with this disorder, and calculate gene frequencies of human leukocyte antigen (HLA) class II alleles in these patients. DESIGN: Fifty-three patients with the diagnosis of pars planitis underwent clinical record review or telephone interview for follow-up or both; 32 of these underwent phlebotomy for analysis of HLA class II alleles. MAIN OUTCOME MEASURES: Outcomes included visual acuity, occurrence of multiple sclerosis and/or optic neuritis, and HLA class II gene frequencies. RESULTS: With a mean follow-up of 2 years, approximately 90% of patients maintained a visual acuity better than 20/40 in at least one eye. The most frequently encountered ophthalmic complications included cystoid macular edema, cataract, and epiretinal membrane formation. Of 37 patients with pars planitis who had medical or neurologic follow-up evaluations, 6 (16.2%) developed multiple sclerosis. The HLA-DR15 allele, coding for one of the two HLA-DR2 subtypes, was associated with pars planitis (odds ratio = 2.86, 95% confidence interval = 1.42-5.78, P = 0.004). CONCLUSIONS: A common immunogenetic predisposition to multiple sclerosis and pars planitis may be associated with the HLA-DR15 allele. This association may represent genetic linkage to the HLA-DR locus or a role for the HLA-DR15 gene product in the pathogenesis of both of these diseases.

Duke Scholars

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

March 1999

Volume

106

Issue

3

Start / End Page

594 / 599

Location

United States

Related Subject Headings

  • Visual Acuity
  • Prognosis
  • Pars Planitis
  • Optic Neuritis
  • Ophthalmology & Optometry
  • Multiple Sclerosis
  • Middle Aged
  • Male
  • Humans
  • HLA-DR Serological Subtypes
 

Citation

APA
Chicago
ICMJE
MLA
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Raja, S. C., Jabs, D. A., Dunn, J. P., Fekrat, S., Machan, C. H., Marsh, M. J., & Bressler, N. M. (1999). Pars planitis: clinical features and class II HLA associations. Ophthalmology, 106(3), 594–599. https://doi.org/10.1016/S0161-6420(99)90122-7
Raja, S. C., D. A. Jabs, J. P. Dunn, S. Fekrat, C. H. Machan, M. J. Marsh, and N. M. Bressler. “Pars planitis: clinical features and class II HLA associations.Ophthalmology 106, no. 3 (March 1999): 594–99. https://doi.org/10.1016/S0161-6420(99)90122-7.
Raja SC, Jabs DA, Dunn JP, Fekrat S, Machan CH, Marsh MJ, et al. Pars planitis: clinical features and class II HLA associations. Ophthalmology. 1999 Mar;106(3):594–9.
Raja, S. C., et al. “Pars planitis: clinical features and class II HLA associations.Ophthalmology, vol. 106, no. 3, Mar. 1999, pp. 594–99. Pubmed, doi:10.1016/S0161-6420(99)90122-7.
Raja SC, Jabs DA, Dunn JP, Fekrat S, Machan CH, Marsh MJ, Bressler NM. Pars planitis: clinical features and class II HLA associations. Ophthalmology. 1999 Mar;106(3):594–599.
Journal cover image

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

March 1999

Volume

106

Issue

3

Start / End Page

594 / 599

Location

United States

Related Subject Headings

  • Visual Acuity
  • Prognosis
  • Pars Planitis
  • Optic Neuritis
  • Ophthalmology & Optometry
  • Multiple Sclerosis
  • Middle Aged
  • Male
  • Humans
  • HLA-DR Serological Subtypes