The pathogenesis of insulin resistance in children: metabolic complications and the roles of diet, exercise and pharmacotherapy in the prevention of type 2 diabetes.
In this manuscript we discuss the pathogenesis of type 2 diabetes in children, emphasizing the central importance of obesity, insulin resistance, dyslipidemia, hypertension and endothelial dysfunction. We then review critically the benefits of diet, exercise and pharmacotherapy in preventing type 2 diabetes and vascular complications in high risk children and young adults.
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