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The pathogenesis of insulin resistance in children: metabolic complications and the roles of diet, exercise and pharmacotherapy in the prevention of type 2 diabetes.

Publication ,  Journal Article
Artz, E; Freemark, M
Published in: Pediatr Endocrinol Rev
March 2004

In this manuscript we discuss the pathogenesis of type 2 diabetes in children, emphasizing the central importance of obesity, insulin resistance, dyslipidemia, hypertension and endothelial dysfunction. We then review critically the benefits of diet, exercise and pharmacotherapy in preventing type 2 diabetes and vascular complications in high risk children and young adults.

Duke Scholars

Published In

Pediatr Endocrinol Rev

ISSN

1565-4753

Publication Date

March 2004

Volume

1

Issue

3

Start / End Page

296 / 309

Location

Israel

Related Subject Headings

  • Risk Factors
  • Insulin Resistance
  • Insulin
  • Hypoglycemic Agents
  • Humans
  • Exercise Therapy
  • Endocrinology & Metabolism
  • Diet, Diabetic
  • Diabetes Mellitus, Type 2
  • Child
 

Published In

Pediatr Endocrinol Rev

ISSN

1565-4753

Publication Date

March 2004

Volume

1

Issue

3

Start / End Page

296 / 309

Location

Israel

Related Subject Headings

  • Risk Factors
  • Insulin Resistance
  • Insulin
  • Hypoglycemic Agents
  • Humans
  • Exercise Therapy
  • Endocrinology & Metabolism
  • Diet, Diabetic
  • Diabetes Mellitus, Type 2
  • Child