A vaginal fluid simulant.

Journal Article (Review;Journal Article)

A fluid medium was developed to simulate the fluid produced in the human vagina. The composition of the medium was based on an extensive review of the literature on constituents of human vaginal secretions. In choosing the ingredients for this medium, the goal was to emphasize properties that influence interactions of vaginal fluid with topical contraceptive, prophylactic, or therapeutic products. Among these properties, pH and osmolarity play a dominant role in physicochemical processes that govern drug release and distribution.

Full Text

Duke Authors

Cited Authors

  • Owen, DH; Katz, DF

Published Date

  • February 1999

Published In

Volume / Issue

  • 59 / 2

Start / End Page

  • 91 - 95

PubMed ID

  • 10361623

Electronic International Standard Serial Number (EISSN)

  • 1879-0518

International Standard Serial Number (ISSN)

  • 0010-7824

Digital Object Identifier (DOI)

  • 10.1016/s0010-7824(99)00010-4

Language

  • eng