Rheological properties of contraceptive gels.

Published

Journal Article

The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol II, and Advantage-S included stress growth, stress relaxation and residual stress, and the shear rate dependence of viscosity. All gels exhibited non-Newtonian behavior including shear thinning and viscoelasticity. Conceptrol and Gynol II had no residual stress, while both KY Plus and Advantage-S did. The gels differed in their response to dilution with vaginal fluid simulant.

Full Text

Duke Authors

Cited Authors

  • Owen, DH; Peters, JJ; Katz, DF

Published Date

  • December 2000

Published In

Volume / Issue

  • 62 / 6

Start / End Page

  • 321 - 326

PubMed ID

  • 11239620

Pubmed Central ID

  • 11239620

Electronic International Standard Serial Number (EISSN)

  • 1879-0518

International Standard Serial Number (ISSN)

  • 0010-7824

Digital Object Identifier (DOI)

  • 10.1016/s0010-7824(00)00184-0

Language

  • eng