A review of the physical and chemical properties of human semen and the formulation of a semen simulant.


Journal Article (Review)

A fluid medium was developed to simulate the salient physical and chemical properties of human semen. The composition of the medium was based upon an extensive review of the literature on constituents of human semen. In choosing the ingredients for this medium, the goal was to emphasize properties that influence interactions of human semen with topical contraceptive, prophylactic, or therapeutic products. Among these properties, pH and buffering capacity, osmolarity, ionic strength, and rheological properties play dominant roles in the physico-chemical processes that govern drug release kinetics and delivery vehicle distribution.

Full Text

Duke Authors

Cited Authors

  • Owen, DH; Katz, DF

Published Date

  • July 2005

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 459 - 469

PubMed ID

  • 15955884

Pubmed Central ID

  • 15955884

Electronic International Standard Serial Number (EISSN)

  • 1939-4640

International Standard Serial Number (ISSN)

  • 0196-3635

Digital Object Identifier (DOI)

  • 10.2164/jandrol.04104


  • eng