Engineering novel synthetic biological systems


Journal Article

Engineering principles and new applications for the nascent field of synthetic biology are just beginning to be explored. Here, we report the engineering of four novel synthetic biological systems: (1) a Bacterial Dynamo, for generating electricity using modified magnetotactic bacteria on a microfabricated device; (2) Cancer StickyBots, for targeting and destroying tumour cells using engineered Escherichia coli cells; (3) Human Encryption, an information encoding, storage, and retrieval scheme for potential security and medical diagnostic applications; and (4) X-Verter, new strategies and tools for biological circuit design and BioBrick management. While each of these systems had distinct aims, they shared a common philosophy of rationally building useful and beneficial synthetic biological systems using fundamental engineering principles. They also demonstrated the potential usefulness of BioBricks and contributed to the Registry of Standard Biological Parts and synthetic biology community-at-large. © 2007 The Institution of Engineering and Technology.

Full Text

Duke Authors

Cited Authors

  • Reza, F; Chandran, K; Feltz, M; Heinz, A; Josephs, E; O'Brien, P; Van Dyke, B; Chung, H; Indurkhya, S; Lakhani, N; Lee, J; Lin, S; Tang, N; Labean, T; You, L; Yuan, F; Tian, J

Published Date

  • August 15, 2007

Published In

Volume / Issue

  • 1 / 1-2

Start / End Page

  • 48 - 52

Electronic International Standard Serial Number (EISSN)

  • 1752-1408

International Standard Serial Number (ISSN)

  • 1752-1394

Digital Object Identifier (DOI)

  • 10.1049/iet-stb:20060004

Citation Source

  • Scopus