Genitourinary complications of sickle cell disease.

Published

Journal Article (Review)

PURPOSE: In the last half century the molecular biology, pathophysiology and natural history of sickle cell disease have been well defined. Sickle cell disease causes microvascular occlusion, which is manifested in most organ systems. The genitourinary tract is most commonly affected by hematuria, urinary tract infection and priapism but other more serious sequelae have been identified. MATERIALS AND METHODS: We performed a computerized MEDLINE search from 1965 to the present and a bibliographic review of cross references. These references were analyzed for meaningful findings and case reports. RESULTS: The diagnosis and management of sickle cell disease have advanced rapidly with a significant increase in the life expectancy of affected patients and recognition of a greater number of genitourinary complications. Renal function may be mildly altered or lost completely. Patients with sickle cell disease are at increased risk for urinary tract infection. Priapism is a painful complication of sickle cell disease that is poorly understood and challenging to treat and prevent. Testicular infarction has also been noted. Furthermore, renal medullary carcinoma, a highly lethal tumor, develops almost exclusively in young patients with sickle cell trait. CONCLUSIONS: Heightened awareness of the genitourinary complications of sickle cell disease may prevent end stage disease, including renal failure and impotence. New forms of therapy for sickle cell disease, such as hydroxyurea, may prevent these complications in the future.

Full Text

Duke Authors

Cited Authors

  • Bruno, D; Wigfall, DR; Zimmerman, SA; Rosoff, PM; Wiener, JS

Published Date

  • September 2001

Published In

Volume / Issue

  • 166 / 3

Start / End Page

  • 803 - 811

PubMed ID

  • 11490223

Pubmed Central ID

  • 11490223

International Standard Serial Number (ISSN)

  • 0022-5347

Language

  • eng

Conference Location

  • United States