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Myc requires distinct E2F activities to induce S phase and apoptosis.

Publication ,  Journal Article
Leone, G; Sears, R; Huang, E; Rempel, R; Nuckolls, F; Park, CH; Giangrande, P; Wu, L; Saavedra, HI; Field, SJ; Thompson, MA; Yang, H ...
Published in: Mol Cell
July 2001

Previous work has shown that the Myc transcription factor induces transcription of the E2F1, E2F2, and E2F3 genes. Using primary mouse embryo fibroblasts deleted for individual E2F genes, we now show that Myc-induced S phase and apoptosis requires distinct E2F activities. The ability of Myc to induce S phase is impaired in the absence of either E2F2 or E2F3 but not E2F1 or E2F4. In contrast, the ability of Myc to induce apoptosis is markedly reduced in cells deleted for E2F1 but not E2F2 or E2F3. From this data, we propose that the induction of specific E2F activities is an essential component in the Myc pathways that control cell proliferation and cell fate decisions.

Duke Scholars

Published In

Mol Cell

DOI

ISSN

1097-2765

Publication Date

July 2001

Volume

8

Issue

1

Start / End Page

105 / 113

Location

United States

Related Subject Headings

  • Transfection
  • Transcription Factors
  • S Phase
  • Recombinant Fusion Proteins
  • Proto-Oncogene Proteins c-myc
  • Mice, Knockout
  • Mice
  • Fibroblasts
  • E2F4 Transcription Factor
  • E2F3 Transcription Factor
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Leone, G., Sears, R., Huang, E., Rempel, R., Nuckolls, F., Park, C. H., … Nevins, J. R. (2001). Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell, 8(1), 105–113. https://doi.org/10.1016/s1097-2765(01)00275-1
Leone, G., R. Sears, E. Huang, R. Rempel, F. Nuckolls, C. H. Park, P. Giangrande, et al. “Myc requires distinct E2F activities to induce S phase and apoptosis.Mol Cell 8, no. 1 (July 2001): 105–13. https://doi.org/10.1016/s1097-2765(01)00275-1.
Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, et al. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul;8(1):105–13.
Leone, G., et al. “Myc requires distinct E2F activities to induce S phase and apoptosis.Mol Cell, vol. 8, no. 1, July 2001, pp. 105–13. Pubmed, doi:10.1016/s1097-2765(01)00275-1.
Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul;8(1):105–113.
Journal cover image

Published In

Mol Cell

DOI

ISSN

1097-2765

Publication Date

July 2001

Volume

8

Issue

1

Start / End Page

105 / 113

Location

United States

Related Subject Headings

  • Transfection
  • Transcription Factors
  • S Phase
  • Recombinant Fusion Proteins
  • Proto-Oncogene Proteins c-myc
  • Mice, Knockout
  • Mice
  • Fibroblasts
  • E2F4 Transcription Factor
  • E2F3 Transcription Factor