Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience.

Published

Journal Article

UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n=5; 5/6 n=2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

Full Text

Duke Authors

Cited Authors

  • Adamkiewicz, TV; Szabolcs, P; Haight, A; Baker, KS; Staba, S; Kedar, A; Chiang, KY; Krishnamurti, L; Boyer, MW; Kurtzberg, J; Wagner, JE; Wingard, JR; Yeager, AM

Published Date

  • September 2007

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 641 - 644

PubMed ID

  • 17663687

Pubmed Central ID

  • 17663687

International Standard Serial Number (ISSN)

  • 1397-3142

Digital Object Identifier (DOI)

  • 10.1111/j.1399-3046.2007.00725.x

Language

  • eng

Conference Location

  • Denmark