Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning.

Journal Article (Journal Article)

Sickle cell disease can be corrected by hematopoietic cell transplantation but success is limited by low availability of matched related/unrelated donors and comorbidities leading to the increased transplant-related morbidity/mortality. There is a need for expanded donor pools and reduced intensity regimens. We describe a case of a second unrelated cord blood transplant after a novel preparative regimen in a child with sickle cell disease related stroke and liver fibrosis. Hydroxyurea, rituximab, and alemtuzumab were followed by thiotepa and low dose total body irradiation before unrelated cord blood transplant. Rapid full donor chimerism and improved performance status was achieved and sustained over 2 years after transplant.

Full Text

Duke Authors

Cited Authors

  • Mazur, M; Kurtzberg, J; Halperin, E; Ciocci, G; Szabolcs, P

Published Date

  • December 2006

Published In

Volume / Issue

  • 28 / 12

Start / End Page

  • 840 - 844

PubMed ID

  • 17164657

International Standard Serial Number (ISSN)

  • 1077-4114

Digital Object Identifier (DOI)

  • 10.1097/MPH.0b013e31802d3e53


  • eng

Conference Location

  • United States