Accuracy of salivary estriol testing compared to traditional risk factor assessment in predicting preterm birth.


Journal Article

OBJECTIVE:The objective was to compare the predictive accuracy (percentage of correct vs incorrect predictions) of salivary estriol levels (SalEst; Biex, Inc, Dublin, Calif) with that of the modified Creasy score for predicting preterm labor followed by preterm delivery. STUDY DESIGN:A triple-blinded prospective trial was conducted at 8 US centers. RESULTS:Among 601 evaluable patients, serial salivary estriol testing correctly predicted the appropriate outcome 91% of the time and the Creasy scoring method correctly predicted the appropriate outcome 75% of the time (McNemar test P <. 001). Among subjects with Creasy scores >/=10 (high-risk group, n = 152), use of salivary estriol testing correctly predicted the end point 87% of the time, compared with only 7.2% correctly predicted by modified Creasy scoring (McNemar test P <.001). CONCLUSION:Salivary estriol assessment was more accurate in predicting outcome than was modified Creasy scoring.

Full Text

Cited Authors

  • Heine, RP; McGregor, JA; Dullien, VK

Published Date

  • January 1999

Published In

Volume / Issue

  • 180 / 1 Pt 3

Start / End Page

  • S214 - S218

PubMed ID

  • 9914620

Pubmed Central ID

  • 9914620

Electronic International Standard Serial Number (EISSN)

  • 1097-6868

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/s0002-9378(99)70703-9


  • eng