Neutrophil granule products: can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes?


Journal Article

OBJECTIVE:Our purpose was to determine whether maternal plasma levels of neutrophil granule products are elevated in patients with chorioamnionitis after preterm premature rupture of membranes (PROM). STUDY DESIGN:Fifty-two patients between 24 and 34 weeks' gestation with preterm PROM were included. Plasma samples for defensins and lactoferrin were collected throughout latency. Fifty-two control subjects between 26 and 30 weeks' gestation were recruited for baseline levels. RESULTS:Mean control defensin levels were compared with mean defensin levels on admission (668 ng/mL vs 5665 ng/mL, P<.01). Mean defensin levels on admission in patients without chorioamnionitis were compared with those of patients in whom histologic chorioamnionitis developed (520 ng/mL vs 9163 ng/mL, P<.01). The same relationships were not demonstrated for lactoferrin. With use a defensin value of 1500 ng/mL on admission, the sensitivity is 76% and specificity is 94% in predicting histologic chorioamnionitis. CONCLUSIONS:Maternal plasma levels of defensins are markers of histologic chorioamnionitis in patients after preterm PROM.

Full Text

Cited Authors

  • Grable, IA; Heine, RP

Published Date

  • September 2003

Published In

Volume / Issue

  • 189 / 3

Start / End Page

  • 808 - 812

PubMed ID

  • 14526319

Pubmed Central ID

  • 14526319

Electronic International Standard Serial Number (EISSN)

  • 1097-6868

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1067/s0002-9378(03)00893-7


  • eng