Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy.


Journal Article

The purpose of this study was to define the impact of asymptomatic trichomoniasis on lower genital tract neutrophil activation in pregnancy.In this nested cohort study, pelvic examination was performed on 65 asymptomatic pregnant women between 7 and 22 weeks' with vaginal pH > 4.4. Concentrations of cervical interleukin-8 and alpha-defensin were determined using enzyme-linked immunosorbent assay (ELISA). Trichomonas vaginalis was detected by culture.Median concentrations of vaginal fluid neutrophil defensins and cervical interleukin-8 were significantly greater among women with asymptomatic trichomoniasis (median defensins 18,622 ng/mL, median IL-8 9244 pg/mL) than their uninfected counterparts (median defensins 5144 ng/mL, median IL-8 2044 pg/mL) (P < .001). All women with asymptomatic trichomoniasis had detectable defensin and interleukin-8 concentrations.Asymptomatic trichomoniasis in pregnancy is accompanied by a state of neutrophil activation.

Full Text

Cited Authors

  • Simhan, HN; Anderson, BL; Krohn, MA; Heine, RP; Martinez de Tejada, B; Landers, DV; Hillier, SL

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 196 / 1

Start / End Page

  • 59.e1 - 59.e5

PubMed ID

  • 17240235

Pubmed Central ID

  • 17240235

Electronic International Standard Serial Number (EISSN)

  • 1097-6868

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2006.08.035


  • eng