Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy.

Journal Article

OBJECTIVE: The purpose of this study was to define the impact of asymptomatic trichomoniasis on lower genital tract neutrophil activation in pregnancy. STUDY DESIGN: In this nested cohort study, pelvic examination was performed on 65 asymptomatic pregnant women between 7 and 22 weeks' with vaginal pH > 4.4. Concentrations of cervical interleukin-8 and alpha-defensin were determined using enzyme-linked immunosorbent assay (ELISA). Trichomonas vaginalis was detected by culture. RESULTS: Median concentrations of vaginal fluid neutrophil defensins and cervical interleukin-8 were significantly greater among women with asymptomatic trichomoniasis (median defensins 18,622 ng/mL, median IL-8 9244 pg/mL) than their uninfected counterparts (median defensins 5144 ng/mL, median IL-8 2044 pg/mL) (P < .001). All women with asymptomatic trichomoniasis had detectable defensin and interleukin-8 concentrations. CONCLUSION: Asymptomatic trichomoniasis in pregnancy is accompanied by a state of neutrophil activation.

Full Text

Cited Authors

  • Simhan, HN; Anderson, BL; Krohn, MA; Heine, RP; Martinez de Tejada, B; Landers, DV; Hillier, SL

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 196 / 1

Start / End Page

  • 59.e1 - 59.e5

PubMed ID

  • 17240235

Electronic International Standard Serial Number (EISSN)

  • 1097-6868

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2006.08.035

Language

  • eng

Conference Location

  • United States