The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis.

Published

Journal Article

OBJECTIVE: To evaluate the pharmacokinetics and cost of once-daily dosing with gentamicin in women with postpartum endometritis. METHODS: Gentamicin in a single daily dose of 4.5 mg/kg was administered intravenously to 10 women with postpartum endometritis. Peak and trough gentamicin levels were measured, and nephrotoxicity and clinical ototoxicity were monitored. Pharmacokinetic data were analyzed, and a cost analysis of once-daily gentamicin administration was performed. RESULTS: The mean elimination constant was 0.105 +/- 0.008 L/h, and the mean volume of distribution was 0.34 +/- 0.07 L/kg. Mean peak gentamicin levels exceeded 11 mg/L, and all trough levels were < 0.3 mg/L. Cost savings of 44% were achieved with once-daily dosing of gentamicin, compared with traditional thrice-daily dosing. CONCLUSIONS: Once-daily dosing with gentamicin in women with postpartum endometritis achieves therapeutic peak levels without drug accumulation. Substantial cost savings are realized with this dosing regimen.

Full Text

Cited Authors

  • Sunyecz, JA; Wiesenfeld, HC; Heine, RP

Published Date

  • January 1998

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 160 - 162

PubMed ID

  • 9812247

Pubmed Central ID

  • 9812247

Electronic International Standard Serial Number (EISSN)

  • 1098-0997

International Standard Serial Number (ISSN)

  • 1064-7449

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1098-0997(1998)6:4<160::AID-IDOG4>3.0.CO;2-C

Language

  • eng