Cost-effectiveness of the oral adsorbent AST-120 versus placebo for chronic kidney disease.

Journal Article (Journal Article)

AIM: This study was designed to evaluate the cost-effectiveness of AST-120, an oral adsorbent that attenuates the progression of chronic kidney disease. METHODS: We developed a Markov model with six health states, including four levels of serum creatinine, haemodialysis and death, using data from a randomized clinical trial conducted in Japan. Direct costs relevant to chronic kidney disease were calculated from a Japanese reimbursement perspective. Projected quality-adjusted life years (QALY) and costs were compared between the AST-120 and placebo groups. The target population was nondiabetic patients with serum creatinine levels from 5.0 to 8.0 mg/dL (442-707 micromol/L) at baseline. Probabilistic sensitivity analysis was performed to evaluate the stability of the results. RESULTS: At 3 years, mean total costs per patient were estimated at 6.67 million yen (US$56,982) in the AST-120 group and 9.38 million yen (US$80,196) in the placebo group. Mean total costs were 2.72 million yen (US$23,205) lower among patients receiving AST-120. QALY per patient were 0.295 (approximately 3.5 months) greater for patients receiving AST-120 than for those receiving placebo over 3 years. The finding that treatment with AST-120 dominated placebo (i.e. was less costly and resulted in more QALY) was upheld in sensitivity analyses. CONCLUSION: The use of AST-120 in patients with advanced chronic kidney disease may help to slow the rate of growth in expenditures for kidney disease.

Full Text

Duke Authors

Cited Authors

  • Takahashi, T; Reed, SD; Schulman, KA

Published Date

  • October 2008

Published In

Volume / Issue

  • 13 / 5

Start / End Page

  • 419 - 427

PubMed ID

  • 18518936

Electronic International Standard Serial Number (EISSN)

  • 1440-1797

Digital Object Identifier (DOI)

  • 10.1111/j.1440-1797.2008.00960.x


  • eng

Conference Location

  • Australia