Shared features in the pathobiology of babesiosis and malaria.

Published

Journal Article (Review)

The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of livestock and more recently as an emerging health problem in humans, is caused by related intraerythrocytic protozoa with a similar pathogenesis and clinical course. Recent studies of cytokine activation and erythrocyte cytoadherence in babesiosis and malaria have exploited these similarities to provide new insights into malaria pathobiology. Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions.

Full Text

Duke Authors

Cited Authors

  • Krause, PJ; Daily, J; Telford, SR; Vannier, E; Lantos, P; Spielman, A

Published Date

  • December 2007

Published In

Volume / Issue

  • 23 / 12

Start / End Page

  • 605 - 610

PubMed ID

  • 17988944

Pubmed Central ID

  • 17988944

International Standard Serial Number (ISSN)

  • 1471-4922

Digital Object Identifier (DOI)

  • 10.1016/j.pt.2007.09.005

Language

  • eng

Conference Location

  • England