Shared features in the pathobiology of babesiosis and malaria.
Journal Article (Review)
The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of livestock and more recently as an emerging health problem in humans, is caused by related intraerythrocytic protozoa with a similar pathogenesis and clinical course. Recent studies of cytokine activation and erythrocyte cytoadherence in babesiosis and malaria have exploited these similarities to provide new insights into malaria pathobiology. Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions.
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Duke Authors
Cited Authors
- Krause, PJ; Daily, J; Telford, SR; Vannier, E; Lantos, P; Spielman, A
Published Date
- December 2007
Published In
Volume / Issue
- 23 / 12
Start / End Page
- 605 - 610
PubMed ID
- 17988944
Pubmed Central ID
- 17988944
International Standard Serial Number (ISSN)
- 1471-4922
Digital Object Identifier (DOI)
- 10.1016/j.pt.2007.09.005
Language
- eng
Conference Location
- England