Statins and cancer risk: what do we know and where do we go from here?

Published

Journal Article

The relationship between statin use and cancer risk has been evaluated in numerous observational studies and as a secondary outcome in randomized controlled trials evaluating the effects of statins on cardiovascular outcomes. Although there are plausible biologic mechanisms to suggest that statins could inhibit cellular proliferation, the epidemiologic data do not show a consistent reduction in cancer risk among statin users. Despite the current lack of evidence for a chemopreventive effect, there are several methodologic considerations in the studies reported to date that prevent a definitive conclusion that statins do not reduce cancer risk. Given the widespread use of statins, continued monitoring of their risks and benefits is warranted.

Full Text

Duke Authors

Cited Authors

  • Moorman, PG; Hamilton, RJ

Published Date

  • March 2007

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 194 - 196

PubMed ID

  • 17301705

Pubmed Central ID

  • 17301705

Electronic International Standard Serial Number (EISSN)

  • 1531-5487

International Standard Serial Number (ISSN)

  • 1044-3983

Digital Object Identifier (DOI)

  • 10.1097/01.ede.0000254699.31405.e2

Language

  • eng