The use of single-nucleotide polymorphism maps in pharmacogenomics.


Journal Article (Review)

Single-nucleotide polymorphisms (SNPs), common variations among the DNA of individuals, are being uncovered and assembled into large SNP databases that promise to enable the dissection of the genetic basis of disease and drug response (i.e., pharmacogenomics). Although great strides have been made in understanding the diversity of the human genome, such as the frequency, distribution, and type of genetic variation that exists, the feasibility of applying this information to uncover useful pharmacogenomic markers is uncertain. The health care industry is clamoring for access to SNP databases for use in research in the hope of revolutionizing the drug development process. As the reality of using SNPs to uncover drug response markers is rarely addressed, this review discusses practical issues, such as patient sample size, SNP density and genome coverage, and data interpretation, that will be important for determining the applicability of pharmacogenomic information to medical practice.

Full Text

Duke Authors

Cited Authors

  • McCarthy, JJ; Hilfiker, R

Published Date

  • May 2000

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 505 - 508

PubMed ID

  • 10802616

Pubmed Central ID

  • 10802616

International Standard Serial Number (ISSN)

  • 1087-0156

Digital Object Identifier (DOI)

  • 10.1038/75360


  • eng

Conference Location

  • United States