Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups.

Published

Journal Article

Testing the fit of population data to Hardy-Weinberg proportions is crucial in the validation of many current approaches in population genetic studies. In this paper, we tested fit to Hardy-Weinberg proportions using exact approaches for both the overall and individual heterozygote genotype data of four HLA Class II loci: DRB1, DQA1, DQB1, and DPB1, from 26 human populations. Eighty of 99 overall tests fit the Hardy-Weinberg expectation (73% for DRB1, 89% for DQA1, 81% for DQB1 and 81% for DPB1). Deviations from Hardy-Weinberg proportions were both locus and group specific. Although we could not rule out other mechanisms at work, the individual test results indicated that the departure was possibly partly due to recent admixture. Evidence for selection and other sources of deviation are also discussed.

Full Text

Duke Authors

Cited Authors

  • Chen, JJ; Hollenbach, JA; Trachtenberg, EA; Just, JJ; Carrington, M; Rønningen, KS; Begovich, A; King, MC; McWeeney, S; Mack, SJ; Erlich, HA; Thomson, G

Published Date

  • December 1999

Published In

Volume / Issue

  • 54 / 6

Start / End Page

  • 533 - 542

PubMed ID

  • 10674966

Pubmed Central ID

  • 10674966

International Standard Serial Number (ISSN)

  • 0001-2815

Digital Object Identifier (DOI)

  • 10.1034/j.1399-0039.1999.540601.x

Language

  • eng

Conference Location

  • England