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Treatment of tinnitus with gabapentin: a pilot study.

Publication ,  Journal Article
Witsell, DL; Hannley, MT; Stinnet, S; Tucci, DL
Published in: Otol Neurotol
January 2007

OBJECTIVE: To evaluate the effectiveness of gabapentin (Neurontin) improve the disease-specific quality of life in patients with moderate tinnitus. STUDY DESIGN: Randomized, double blind, placebo-controlled clinical trial. SETTING: Single-center academic outpatient otolaryngology practice. INTERVENTION: Gabapentin 1800 mg daily versus placebo. MAIN OUTCOME MEASURES: The study design is a randomized, double blind placebo controlled single site trial conducted in an academic medical center. Inclusion criteria included patients between ages 18 and 70 with a complaint of nonpulsatile, subjective tinnitus, bilateral or unilateral, greater than 3 months in duration. The primary outcome measure is the Tinnitus Handicap Inventory; secondary measures include the Profile of Mood States (POMS) rating scale, subjective tinnitus severity. The null hypothesis addressed in this study is that the drug would not result in significant alleviation of the symptom of tinnitus. RESULTS: Seventy-six patients completed the trial; of these 52 received the drug. No significant differences were found between the two groups after 5 weeks of treatment with gabapentin. CONCLUSION: There is insufficient evidence to support the effectiveness of gabapentin in the treatment of tinnitus.

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Published In

Otol Neurotol

DOI

ISSN

1531-7129

Publication Date

January 2007

Volume

28

Issue

1

Start / End Page

11 / 15

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Tinnitus
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Quality of Life
  • Pilot Projects
  • Otorhinolaryngology
  • Mood Disorders
  • Middle Aged
  • Male
 

Citation

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Witsell, D. L., Hannley, M. T., Stinnet, S., & Tucci, D. L. (2007). Treatment of tinnitus with gabapentin: a pilot study. Otol Neurotol, 28(1), 11–15. https://doi.org/10.1097/01.mao.0000235967.53474.93
Witsell, David L., Maureen T. Hannley, Sandra Stinnet, and Debara L. Tucci. “Treatment of tinnitus with gabapentin: a pilot study.Otol Neurotol 28, no. 1 (January 2007): 11–15. https://doi.org/10.1097/01.mao.0000235967.53474.93.
Witsell DL, Hannley MT, Stinnet S, Tucci DL. Treatment of tinnitus with gabapentin: a pilot study. Otol Neurotol. 2007 Jan;28(1):11–5.
Witsell, David L., et al. “Treatment of tinnitus with gabapentin: a pilot study.Otol Neurotol, vol. 28, no. 1, Jan. 2007, pp. 11–15. Pubmed, doi:10.1097/01.mao.0000235967.53474.93.
Witsell DL, Hannley MT, Stinnet S, Tucci DL. Treatment of tinnitus with gabapentin: a pilot study. Otol Neurotol. 2007 Jan;28(1):11–15.

Published In

Otol Neurotol

DOI

ISSN

1531-7129

Publication Date

January 2007

Volume

28

Issue

1

Start / End Page

11 / 15

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Tinnitus
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Quality of Life
  • Pilot Projects
  • Otorhinolaryngology
  • Mood Disorders
  • Middle Aged
  • Male