PIN1, the cell cycle and cancer.

Published

Journal Article (Review)

PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and so affect protein function and/or stability. PIN1 regulates a number of proteins important for cell-cycle progression and, based on gain- and loss-of-function studies, is presumed to operate as a molecular timer of this important process. Therefore, it seems logical that alterations in the level of PIN1 can influence hyperproliferative diseases such as cancer. However, the precise role of PIN1 in cancer remains controversial.

Full Text

Duke Authors

Cited Authors

  • Yeh, ES; Means, AR

Published Date

  • May 2007

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 381 - 388

PubMed ID

  • 17410202

Pubmed Central ID

  • 17410202

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

International Standard Serial Number (ISSN)

  • 1474-175X

Digital Object Identifier (DOI)

  • 10.1038/nrc2107

Language

  • eng