Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.
Publication
, Journal Article
Boukhalfa, H; Lewis, JG; Crumbliss, AL
Published in: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
April 2004
Highly toxic beryllium(II) is divalent metal ion with a high charge density, making it a potential target for binding to bio-molecules rich in O donor groups. In aqueous solution Be2+ binds to ATP and ADP to form 1:1 Be2+:ATP and Be2+:ADP complexes in relatively acidic media. At neutral pH the complex formed undergoes hydrolysis. Be2+ binding to ATP and ADP is much stronger than Ca2+ and Mg2+ binding. The high affinity of Be2+ toward ATP and ADP binding suggests a mechanism relevant to understanding the in vivo chemical toxicity of this metal.
Duke Scholars
Published In
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
DOI
EISSN
1572-8773
ISSN
0966-0844
Publication Date
April 2004
Volume
17
Issue
2
Start / End Page
105 / 109
Related Subject Headings
- Thermodynamics
- Sodium Hydroxide
- Kinetics
- Biochemistry & Molecular Biology
- Beryllium
- Adenosine Triphosphate
- Adenosine Diphosphate
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Boukhalfa, H., Lewis, J. G., & Crumbliss, A. L. (2004). Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, 17(2), 105–109. https://doi.org/10.1023/b:biom.0000018359.25658.9c
Boukhalfa, Hakim, James G. Lewis, and Alvin L. Crumbliss. “Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.” Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine 17, no. 2 (April 2004): 105–9. https://doi.org/10.1023/b:biom.0000018359.25658.9c.
Boukhalfa H, Lewis JG, Crumbliss AL. Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2004 Apr;17(2):105–9.
Boukhalfa, Hakim, et al. “Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.” Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 17, no. 2, Apr. 2004, pp. 105–09. Epmc, doi:10.1023/b:biom.0000018359.25658.9c.
Boukhalfa H, Lewis JG, Crumbliss AL. Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2004 Apr;17(2):105–109.
Published In
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
DOI
EISSN
1572-8773
ISSN
0966-0844
Publication Date
April 2004
Volume
17
Issue
2
Start / End Page
105 / 109
Related Subject Headings
- Thermodynamics
- Sodium Hydroxide
- Kinetics
- Biochemistry & Molecular Biology
- Beryllium
- Adenosine Triphosphate
- Adenosine Diphosphate
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology