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Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.

Publication ,  Journal Article
Boukhalfa, H; Lewis, JG; Crumbliss, AL
Published in: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
April 2004

Highly toxic beryllium(II) is divalent metal ion with a high charge density, making it a potential target for binding to bio-molecules rich in O donor groups. In aqueous solution Be2+ binds to ATP and ADP to form 1:1 Be2+:ATP and Be2+:ADP complexes in relatively acidic media. At neutral pH the complex formed undergoes hydrolysis. Be2+ binding to ATP and ADP is much stronger than Ca2+ and Mg2+ binding. The high affinity of Be2+ toward ATP and ADP binding suggests a mechanism relevant to understanding the in vivo chemical toxicity of this metal.

Duke Scholars

Published In

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

DOI

EISSN

1572-8773

ISSN

0966-0844

Publication Date

April 2004

Volume

17

Issue

2

Start / End Page

105 / 109

Related Subject Headings

  • Thermodynamics
  • Sodium Hydroxide
  • Kinetics
  • Biochemistry & Molecular Biology
  • Beryllium
  • Adenosine Triphosphate
  • Adenosine Diphosphate
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

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ICMJE
MLA
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Boukhalfa, H., Lewis, J. G., & Crumbliss, A. L. (2004). Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, 17(2), 105–109. https://doi.org/10.1023/b:biom.0000018359.25658.9c
Boukhalfa, Hakim, James G. Lewis, and Alvin L. Crumbliss. “Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine 17, no. 2 (April 2004): 105–9. https://doi.org/10.1023/b:biom.0000018359.25658.9c.
Boukhalfa H, Lewis JG, Crumbliss AL. Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2004 Apr;17(2):105–9.
Boukhalfa, Hakim, et al. “Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 17, no. 2, Apr. 2004, pp. 105–09. Epmc, doi:10.1023/b:biom.0000018359.25658.9c.
Boukhalfa H, Lewis JG, Crumbliss AL. Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2004 Apr;17(2):105–109.
Journal cover image

Published In

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

DOI

EISSN

1572-8773

ISSN

0966-0844

Publication Date

April 2004

Volume

17

Issue

2

Start / End Page

105 / 109

Related Subject Headings

  • Thermodynamics
  • Sodium Hydroxide
  • Kinetics
  • Biochemistry & Molecular Biology
  • Beryllium
  • Adenosine Triphosphate
  • Adenosine Diphosphate
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology