Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.

Journal Article (Journal Article)

Highly toxic beryllium(II) is divalent metal ion with a high charge density, making it a potential target for binding to bio-molecules rich in O donor groups. In aqueous solution Be2+ binds to ATP and ADP to form 1:1 Be2+:ATP and Be2+:ADP complexes in relatively acidic media. At neutral pH the complex formed undergoes hydrolysis. Be2+ binding to ATP and ADP is much stronger than Ca2+ and Mg2+ binding. The high affinity of Be2+ toward ATP and ADP binding suggests a mechanism relevant to understanding the in vivo chemical toxicity of this metal.

Full Text

Duke Authors

Cited Authors

  • Boukhalfa, H; Lewis, JG; Crumbliss, AL

Published Date

  • April 2004

Published In

Volume / Issue

  • 17 / 2

Start / End Page

  • 105 - 109

PubMed ID

  • 15088935

Electronic International Standard Serial Number (EISSN)

  • 1572-8773

International Standard Serial Number (ISSN)

  • 0966-0844

Digital Object Identifier (DOI)

  • 10.1023/b:biom.0000018359.25658.9c


  • eng