Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria.
Journal Article
Siderophores based on sugar backbones substituted at the 2,3,4- or 2,3,6 positions with hydroxamic or retro-hydroxamic acid chelating units were synthesized and characterized. The alkyl terminus of the iron-coordinating side chain units facilitate lipophilic interactions. Iron coordination properties and complex stability were investigated by ESI-MS and the CAS-Test. The results were correlated to structure activity relationships determined by microbial growth promotion studies under iron limited conditions using wild type strains and iron transport mutants of Mycobacterium smegmatis.
Full Text
Duke Authors
Cited Authors
- Gebhardt, P; Crumbliss, AL; Miller, MJ; Möllmann, U
Published Date
- February 2008
Published In
Volume / Issue
- 21 / 1
Start / End Page
- 41 - 51
PubMed ID
- 17390213
Pubmed Central ID
- 17390213
Electronic International Standard Serial Number (EISSN)
- 1572-8773
International Standard Serial Number (ISSN)
- 0966-0844
Digital Object Identifier (DOI)
- 10.1007/s10534-007-9091-x
Language
- eng