Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria.
Publication
, Journal Article
Gebhardt, P; Crumbliss, AL; Miller, MJ; Möllmann, U
Published in: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
February 2008
Siderophores based on sugar backbones substituted at the 2,3,4- or 2,3,6 positions with hydroxamic or retro-hydroxamic acid chelating units were synthesized and characterized. The alkyl terminus of the iron-coordinating side chain units facilitate lipophilic interactions. Iron coordination properties and complex stability were investigated by ESI-MS and the CAS-Test. The results were correlated to structure activity relationships determined by microbial growth promotion studies under iron limited conditions using wild type strains and iron transport mutants of Mycobacterium smegmatis.
Duke Scholars
Published In
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
DOI
EISSN
1572-8773
ISSN
0966-0844
Publication Date
February 2008
Volume
21
Issue
1
Start / End Page
41 / 51
Related Subject Headings
- Spectrometry, Mass, Electrospray Ionization
- Siderophores
- Mycobacterium smegmatis
- Mycobacterium
- Molecular Structure
- Magnetic Resonance Spectroscopy
- Hydroxamic Acids
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Gebhardt, P., Crumbliss, A. L., Miller, M. J., & Möllmann, U. (2008). Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria. Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, 21(1), 41–51. https://doi.org/10.1007/s10534-007-9091-x
Gebhardt, Peter, Alvin L. Crumbliss, Marvin J. Miller, and Ute Möllmann. “Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria.” Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine 21, no. 1 (February 2008): 41–51. https://doi.org/10.1007/s10534-007-9091-x.
Gebhardt P, Crumbliss AL, Miller MJ, Möllmann U. Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2008 Feb;21(1):41–51.
Gebhardt, Peter, et al. “Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria.” Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 21, no. 1, Feb. 2008, pp. 41–51. Epmc, doi:10.1007/s10534-007-9091-x.
Gebhardt P, Crumbliss AL, Miller MJ, Möllmann U. Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2008 Feb;21(1):41–51.
Published In
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
DOI
EISSN
1572-8773
ISSN
0966-0844
Publication Date
February 2008
Volume
21
Issue
1
Start / End Page
41 / 51
Related Subject Headings
- Spectrometry, Mass, Electrospray Ionization
- Siderophores
- Mycobacterium smegmatis
- Mycobacterium
- Molecular Structure
- Magnetic Resonance Spectroscopy
- Hydroxamic Acids
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology