Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria.

Journal Article (Journal Article)

Siderophores based on sugar backbones substituted at the 2,3,4- or 2,3,6 positions with hydroxamic or retro-hydroxamic acid chelating units were synthesized and characterized. The alkyl terminus of the iron-coordinating side chain units facilitate lipophilic interactions. Iron coordination properties and complex stability were investigated by ESI-MS and the CAS-Test. The results were correlated to structure activity relationships determined by microbial growth promotion studies under iron limited conditions using wild type strains and iron transport mutants of Mycobacterium smegmatis.

Full Text

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Duke Authors

Crumbliss, Alvin L.

Cited Authors

Gebhardt, P; Crumbliss, AL; Miller, MJ; Möllmann, U

Published Date

February 2008

Published In

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine

Volume / Issue

21 / 1

Start / End Page

41 - 51

PubMed ID

17390213

Electronic International Standard Serial Number (EISSN)

1572-8773

International Standard Serial Number (ISSN)

0966-0844

Digital Object Identifier (DOI)

10.1007/s10534-007-9091-x

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