Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria.

Journal Article

Siderophores based on sugar backbones substituted at the 2,3,4- or 2,3,6 positions with hydroxamic or retro-hydroxamic acid chelating units were synthesized and characterized. The alkyl terminus of the iron-coordinating side chain units facilitate lipophilic interactions. Iron coordination properties and complex stability were investigated by ESI-MS and the CAS-Test. The results were correlated to structure activity relationships determined by microbial growth promotion studies under iron limited conditions using wild type strains and iron transport mutants of Mycobacterium smegmatis.

Full Text

Duke Authors

Cited Authors

  • Gebhardt, P; Crumbliss, AL; Miller, MJ; Möllmann, U

Published Date

  • February 2008

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 41 - 51

PubMed ID

  • 17390213

International Standard Serial Number (ISSN)

  • 0966-0844

Digital Object Identifier (DOI)

  • 10.1007/s10534-007-9091-x

Language

  • eng

Conference Location

  • Netherlands