Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency.
Journal Article (Journal Article)
The syndrome of multiple intestinal atresia with immunodeficiency is a rare, invariably fatal congenital disorder. At 16 months of age, a child with this syndrome underwent liver-small bowel transplantation from a 1-of-6 HLA-matched donor. He acquired full enteral tolerance and normal liver function and has never shown evidence of allograft rejection. After mild graft-versus-host disease developed, studies revealed that more than 99% of his CD3(+) lymphocytes and 50% of his CD19(+) lymphocytes were of donor origin, whereas granulocytes and monocytes remained of recipient origin. He synthesizes polyclonal immunoglobulin G (IgG), IgA, and IgM and has developed antibodies to cytomegalovirus (CMV) and parainfluenza 3. His T lymphocytes are predominately CD3(+)CD4(-)CD8(-) with T-cell receptor gammadelta heterodimers and CD3(+)CD4(-)CD8(+) with CD8alphaalpha homodimers, populations consistent with an intraepithelial lymphocyte phenotypic profile. We postulate that he has engrafted a donor intestine-derived immune system and is incapable of rejecting his engrafted organs.
- Gilroy, RK; Coccia, PF; Talmadge, JE; Hatcher, LI; Pirruccello, SJ; Shaw, BW; Rubocki, RJ; Sudan, DL; Langnas, AN; Horslen, SP
- February 1, 2004
Volume / Issue
- 103 / 3
Start / End Page
- 1171 - 1174
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States