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Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency.

Publication ,  Journal Article
Gilroy, RK; Coccia, PF; Talmadge, JE; Hatcher, LI; Pirruccello, SJ; Shaw, BW; Rubocki, RJ; Sudan, DL; Langnas, AN; Horslen, SP
Published in: Blood
February 1, 2004

The syndrome of multiple intestinal atresia with immunodeficiency is a rare, invariably fatal congenital disorder. At 16 months of age, a child with this syndrome underwent liver-small bowel transplantation from a 1-of-6 HLA-matched donor. He acquired full enteral tolerance and normal liver function and has never shown evidence of allograft rejection. After mild graft-versus-host disease developed, studies revealed that more than 99% of his CD3(+) lymphocytes and 50% of his CD19(+) lymphocytes were of donor origin, whereas granulocytes and monocytes remained of recipient origin. He synthesizes polyclonal immunoglobulin G (IgG), IgA, and IgM and has developed antibodies to cytomegalovirus (CMV) and parainfluenza 3. His T lymphocytes are predominately CD3(+)CD4(-)CD8(-) with T-cell receptor gammadelta heterodimers and CD3(+)CD4(-)CD8(+) with CD8alphaalpha homodimers, populations consistent with an intraepithelial lymphocyte phenotypic profile. We postulate that he has engrafted a donor intestine-derived immune system and is incapable of rejecting his engrafted organs.

Duke Scholars

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

February 1, 2004

Volume

103

Issue

3

Start / End Page

1171 / 1174

Location

United States

Related Subject Headings

  • Tissue Donors
  • Male
  • Lymphocyte Subsets
  • Liver Transplantation
  • Intestine, Small
  • Intestinal Atresia
  • Infant
  • Immunology
  • Immunologic Deficiency Syndromes
  • Immunoglobulins
 

Citation

APA
Chicago
ICMJE
MLA
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Gilroy, R. K., Coccia, P. F., Talmadge, J. E., Hatcher, L. I., Pirruccello, S. J., Shaw, B. W., … Horslen, S. P. (2004). Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency. Blood, 103(3), 1171–1174. https://doi.org/10.1182/blood-2003-04-1187
Gilroy, Richard K., Peter F. Coccia, James E. Talmadge, Lori I. Hatcher, Samuel J. Pirruccello, Byers W. Shaw, Ronald J. Rubocki, Debra L. Sudan, Alan N. Langnas, and Simon P. Horslen. “Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency.Blood 103, no. 3 (February 1, 2004): 1171–74. https://doi.org/10.1182/blood-2003-04-1187.
Gilroy RK, Coccia PF, Talmadge JE, Hatcher LI, Pirruccello SJ, Shaw BW, et al. Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency. Blood. 2004 Feb 1;103(3):1171–4.
Gilroy, Richard K., et al. “Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency.Blood, vol. 103, no. 3, Feb. 2004, pp. 1171–74. Pubmed, doi:10.1182/blood-2003-04-1187.
Gilroy RK, Coccia PF, Talmadge JE, Hatcher LI, Pirruccello SJ, Shaw BW, Rubocki RJ, Sudan DL, Langnas AN, Horslen SP. Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency. Blood. 2004 Feb 1;103(3):1171–1174.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

February 1, 2004

Volume

103

Issue

3

Start / End Page

1171 / 1174

Location

United States

Related Subject Headings

  • Tissue Donors
  • Male
  • Lymphocyte Subsets
  • Liver Transplantation
  • Intestine, Small
  • Intestinal Atresia
  • Infant
  • Immunology
  • Immunologic Deficiency Syndromes
  • Immunoglobulins