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Disaccharidase activities and fat assimilation in pediatric patients after intestinal transplantation.

Publication ,  Journal Article
Kaufman, SS; Lyden, ER; Brown, CR; Iverson, AK; Davis, CK; Sudan, DL; Fox, IJ; Horslen, SP; Shaw, BW; Langnas, AN
Published in: Transplantation
February 15, 2000

BACKGROUND: Intestinal transplantation has become an accepted therapy for short bowel syndrome and other types of intestinal failure. In order to assess digestive capabilities and feeding practices in a group of 22 pediatric patients after intestinal transplantation, we assessed mucosal disaccharidase activities and assimilation of total dietary lipid and vitamin E. Twelve of the patients had undergone contemporaneous liver transplantation. METHODS: Mucosal biopsies were assayed for disaccharidase activities between 15 and 412 days after transplantation in 7 of the 22 when all were receiving some enteral nutrition and were free of rejection. Coefficients of lipid absorption were determined in those patients receiving total enteral feeding (two-thirds polymeric/one-third elemental) between 43 and 1032 days after transplantation; oral vitamin E tolerance tests were done at about the same time. RESULTS: Activities of lactase, sucrase, maltase, and palatinase consistently exceeded reference ranges (P<0.05). Mean coefficient of lipid absorption equaled 86+/-12% and was not influenced by duration of time after transplantation. No patient required dietary lipid restriction. No significant absorption of vitamin E was demonstrated until 160 days after transplantation. Vitamin E absorption did correlate with length of time elapsed after surgery (r=0.64, P<0.0011). CONCLUSIONS: The results of this investigation show that, in the absence of histologic or clinical indications of allograft rejection, pediatric intestinal transplant recipients do not have primary disaccharidase deficiencies. Similarly, absorption of usual dietary lipid content is adequate once weaning from parenteral nutrition is complete. In contrast, early assimilation of vitamin E is poor. Vitamin E absorption subsequently improves, but the mechanism is obscure.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

February 15, 2000

Volume

69

Issue

3

Start / End Page

362 / 365

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Surgery
  • Male
  • Intestines
  • Intestinal Mucosa
  • Intestinal Diseases
  • Infant
  • Humans
  • Graft Rejection
  • Fats
 

Citation

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Kaufman, S. S., Lyden, E. R., Brown, C. R., Iverson, A. K., Davis, C. K., Sudan, D. L., … Langnas, A. N. (2000). Disaccharidase activities and fat assimilation in pediatric patients after intestinal transplantation. Transplantation, 69(3), 362–365. https://doi.org/10.1097/00007890-200002150-00009
Kaufman, S. S., E. R. Lyden, C. R. Brown, A. K. Iverson, C. K. Davis, D. L. Sudan, I. J. Fox, S. P. Horslen, B. W. Shaw, and A. N. Langnas. “Disaccharidase activities and fat assimilation in pediatric patients after intestinal transplantation.Transplantation 69, no. 3 (February 15, 2000): 362–65. https://doi.org/10.1097/00007890-200002150-00009.
Kaufman SS, Lyden ER, Brown CR, Iverson AK, Davis CK, Sudan DL, et al. Disaccharidase activities and fat assimilation in pediatric patients after intestinal transplantation. Transplantation. 2000 Feb 15;69(3):362–5.
Kaufman, S. S., et al. “Disaccharidase activities and fat assimilation in pediatric patients after intestinal transplantation.Transplantation, vol. 69, no. 3, Feb. 2000, pp. 362–65. Pubmed, doi:10.1097/00007890-200002150-00009.
Kaufman SS, Lyden ER, Brown CR, Iverson AK, Davis CK, Sudan DL, Fox IJ, Horslen SP, Shaw BW, Langnas AN. Disaccharidase activities and fat assimilation in pediatric patients after intestinal transplantation. Transplantation. 2000 Feb 15;69(3):362–365.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

February 15, 2000

Volume

69

Issue

3

Start / End Page

362 / 365

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Surgery
  • Male
  • Intestines
  • Intestinal Mucosa
  • Intestinal Diseases
  • Infant
  • Humans
  • Graft Rejection
  • Fats