Acute Budd-Chiari syndrome during pregnancy: surgical treatment and orthotopic liver transplantation with successful completion of the pregnancy.

Journal Article (Journal Article)

A 26-year-old woman presented with acute Budd-Chiari syndrome 18 weeks into a pregnancy. She was found to be heterozygous for the G20210A prothrombin gene mutation. She was treated with portacaval shunt placement and successfully completed the pregnancy, with a healthy baby delivered at 31 weeks' gestation. She developed progressive liver failure after delivery of the child, likely associated with clotting of the shunt, which occurred in the face of full anticoagulation. The patient subsequently underwent a technically complicated orthotopic liver transplantation, but died 10 months after transplantation. This case illustrates the challenges involved in the treatment of Budd-Chiari syndrome, in addition to difficulties balancing the health of a mother and an unborn child. It is the only case of surgical treatment of Budd-Chiari syndrome during pregnancy reported in the literature.

Full Text

Duke Authors

Cited Authors

  • Grant, WJ; McCashland, T; Botha, JF; Shaw, BW; Sudan, DL; Mejia, A; Iyer, K; Langnas, AN

Published Date

  • September 2003

Published In

Volume / Issue

  • 9 / 9

Start / End Page

  • 976 - 979

PubMed ID

  • 12942460

International Standard Serial Number (ISSN)

  • 1527-6465

Digital Object Identifier (DOI)

  • 10.1053/jlts.2003.50134


  • eng

Conference Location

  • United States