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Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease.

Publication ,  Journal Article
Verdonk, RC; Dijkstra, G; Haagsma, EB; Shostrom, VK; Van den Berg, AP; Kleibeuker, JH; Langnas, AN; Sudan, DL
Published in: Am J Transplant
June 2006

Inflammatory bowel disease (IBD) is associated with primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) and can recur or develop de novo after orthotopic liver transplantation (OLT). The aim of this study was to investigate the incidence and severity of IBD after liver transplantation and to perform a multivariate analysis for possible risk factors. In this retrospective study, 91 patients transplanted for PSC or AIH, without prior colectomy, were included. Sixty patients were transplanted for PSC, 31 for AIH. IBD activity before and after OLT and other possible risk factors were analysed in a multivariate model. Forty-nine patients (54%) had IBD before OLT. Forty patients (44%) had active IBD after transplantation: recurrence in 32 and de novo in 8. Cumulative risk for IBD after OLT was 15, 39 and 54% after 1, 5 and 10 years, respectively. In 59% of patients with IBD prior to OLT the disease was more active after transplantation. Risk factors for recurrent disease were: symptoms at time of OLT, short interval of IBD before OLT and use of tacrolimus. 5-aminosalicylates were protective. A cytomegalovirus positive donor/negative recipient combination increased the risk for de novo IBD.

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Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

June 2006

Volume

6

Issue

6

Start / End Page

1422 / 1429

Location

United States

Related Subject Headings

  • Tissue Donors
  • Time Factors
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Recurrence
  • Postoperative Complications
  • Liver Transplantation
  • Inflammatory Bowel Diseases
  • Immunosuppressive Agents
 

Citation

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Verdonk, R. C., Dijkstra, G., Haagsma, E. B., Shostrom, V. K., Van den Berg, A. P., Kleibeuker, J. H., … Sudan, D. L. (2006). Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease. Am J Transplant, 6(6), 1422–1429. https://doi.org/10.1111/j.1600-6143.2006.01333.x
Verdonk, R. C., G. Dijkstra, E. B. Haagsma, V. K. Shostrom, A. P. Van den Berg, J. H. Kleibeuker, A. N. Langnas, and D. L. Sudan. “Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease.Am J Transplant 6, no. 6 (June 2006): 1422–29. https://doi.org/10.1111/j.1600-6143.2006.01333.x.
Verdonk RC, Dijkstra G, Haagsma EB, Shostrom VK, Van den Berg AP, Kleibeuker JH, et al. Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease. Am J Transplant. 2006 Jun;6(6):1422–9.
Verdonk, R. C., et al. “Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease.Am J Transplant, vol. 6, no. 6, June 2006, pp. 1422–29. Pubmed, doi:10.1111/j.1600-6143.2006.01333.x.
Verdonk RC, Dijkstra G, Haagsma EB, Shostrom VK, Van den Berg AP, Kleibeuker JH, Langnas AN, Sudan DL. Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease. Am J Transplant. 2006 Jun;6(6):1422–1429.
Journal cover image

Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

June 2006

Volume

6

Issue

6

Start / End Page

1422 / 1429

Location

United States

Related Subject Headings

  • Tissue Donors
  • Time Factors
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Recurrence
  • Postoperative Complications
  • Liver Transplantation
  • Inflammatory Bowel Diseases
  • Immunosuppressive Agents