Pancreas transplantation: the Nebraska experience.

Journal Article (Journal Article)

In summary, we believe that combined PKT can be performed safely and effectively in the absence of uremia, thereby providing the potential for arresting the progression of diabetic complications prior to the development of ESRD. Furthermore, performing solitary PTx prior to the need for a kidney transplant can be accomplished with morbidity and results comparable to PKT. Rehabilitation potential tends to favor patients undergoing either solitary PTx or preemptive PKT. In selected IDDM patients without end-stage diabetic nephropathy, we believe that solitary PTx or PKT are effective treatment options and need not be considered as preemptive, especially in view of increasing waiting times and the variable progressive nature of diabetic complications. As results continue to improve, solitary PTx may offer a potential solution to the growing number of IDDM patients awaiting kidney transplantation in the United States. Ultimately, the role of solitary PTx in the treatment of IDDM will be determined by long-term studies documenting the prevention or arrest of secondary diabetic complications. In the short-term, improvement in quality of life and rehabilitation potential makes preemptive PKT or solitary PTx important therapeutic alternatives for consideration.

Full Text

Duke Authors

Cited Authors

  • Stratta, RJ; Taylor, RJ; Lowell, JA; Sindhi, R; Sudan, D; Castaldo, P; Weide, LG; Frisbie, K; Cushing, K; Larsen, JL

Published Date

  • 1994

Published In

Start / End Page

  • 265 - 281

PubMed ID

  • 7547548

International Standard Serial Number (ISSN)

  • 0890-9016


  • eng

Conference Location

  • United States