Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection.
INTRODUCTION: The enterocyte-specific protein, intestinal fatty acid binding protein (I-FABP), is detectable in serum only after intestinal injury. Previous studies in animals suggest that I-FABP might be a useful marker of intestinal allograft rejection. MATERIALS AND METHODS: I-FABP was repetitively measured in nine intestinal transplant recipients and correlated with findings of surveillance endoscopy. RESULTS: Average interval between I-FABP determination and biopsy was 3.4 days (SD=4.2 days). Average number of rejection episodes per patient totalled 1.6+/-1.2. General linear modeling demonstrated no tendency for increases in serum FABP to precede histologic graft rejection (P=0.263). Restriction of the analysis to I-FABP determinations 1 day before or on the day of biopsy failed to affect these results. Minor increases in I-FABP were often associated with histologically normal grafts, whereas rejection often occurred when I-FABP was not detectable. DISCUSSION: Serum I-FABP levels do not predict clinical intestinal allograft rejection.
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Related Subject Headings
- Tumor Suppressor Proteins
- Transplantation, Homologous
- Surgery
- Reproducibility of Results
- Neoplasm Proteins
- Monitoring, Physiologic
- Intestines
- Humans
- Graft Rejection
- Fatty Acids
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Suppressor Proteins
- Transplantation, Homologous
- Surgery
- Reproducibility of Results
- Neoplasm Proteins
- Monitoring, Physiologic
- Intestines
- Humans
- Graft Rejection
- Fatty Acids